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Merck
CN

616521

HC-067047

≥98% (HPLC), TRPV4 antagonist, solid

别名:

TRPV4 Antagonist II, HC-067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II, HC067047, HC067047, 2-Methyl-1-(3-morpholinopropyl)-5-phenyl-N-(3-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide, Transient Receptor Potential Vanilloid-4 Antagonist II

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关于此项目

经验公式（希尔记法）:
C26H28F3N3O2
化学文摘社编号:
883031-03-6
分子量:
471.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01571257

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产品名称

TRPV4 Antagonist II, HC-067047, The TRPV4 Antagonist II, HC-067047 controls the biological activity of TRPV4.

SMILES string

FC(F)(F)c1cc(ccc1)NC(=O)c2c([n](c(c2)c4ccccc4)CCCN3CCOCC3)C

InChI key

NCZYSQOTAYFTNM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 50 mg/mL, clear, colorless

shipped in

ambient

Quality Level

100

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General description

A pyrrolocarboxamide compound that potently antagonizes TRP (transient receptor potential) family cation channel TRPV4 activity (IC50 = 17, 48, and 133 nM, respectively, against mouse, human, or rat TRPV4 in whole cell voltage-gated current measurement) in a reversible manner, displaying much reduced potency against human ERG and TRPM8 (IC50 = 368 and 780 nM, respectively) and little or no activity toward hKv1.3, hTRPA1, hTRPC5, hTRPV1/2/3/6, mTRPM7, mTRPV2, or rKv1.2. HC-067047 is efficacious (10 mg/kg via i.p.) in reducing micturition (urination) frequency and increasing voided urine volume of mice and rats suffering from CPA- (Cat. No. 239785) induced cystitis in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Everaerts, W., et al. 2010. Proc. Natl. Acad. Sci. USA107, 19084.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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