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Merck
CN

625625

Trehalose, Dihydrate

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

别名:

Trehalose, Dihydrate, 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside

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关于此项目

经验公式（希尔记法）:
C12H22O11 · 2H2O
化学文摘社编号:
6138-23-4
分子量:
378.33
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
MFCD00071594

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产品名称

Trehalose, Dihydrate, Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

SMILES string

O1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO.O.O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

description

Merck USA index - 14, 9580

assay

≥97.5% (by Assay)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: 100 mg/mL

cation traces

Fe: <5 ppm
heavy metals: <10 ppm

shipped in

ambient

storage temp.

15-25°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

Non-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.
Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.

Other Notes

Sarkar, S., et al. 2007. J. Biol. Chem. In press.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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