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Merck
CN

645900

Triptolide

from Tripterygium wilfordii, ≥95% (HPLC), DEVD-cleaving caspases activator, solid

别名:

Triptolide, Tripterygium wilfordii, PG490

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关于此项目

经验公式（希尔记法）:
C20H24O6
化学文摘社编号:
38748-32-2
分子量:
360.40
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00210565

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产品名称

Triptolide, Tripterygium wilfordii, A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

SMILES string

O1[C@@]32[C@]5(O[C@H]5C[C@@H]6[C@@]3(CCC7=C6COC7=O)C)[C@@H]([C@]4(O[C@H]4[C@@H]21)C(C)C)O

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-CIVMWXNOSA-N

description

RTECS - YK7751000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: no
Primary Target
Activate DEVD-cleaving caspases
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

General description

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

Other Notes

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Biochimica et biophysica acta. Molecular cell research, 1864(10), 1589-1604 (2017-05-31)
Current models imply that the evolutionarily conserved, actin-binding Ezrin-Radixin-Moesin (ERM) proteins perform their activities at the plasma membrane by anchoring membrane proteins to the cortical actin network. Here we show that beside its cytoplasmic functions, the single ERM protein of

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