Name: Triptolide
Brand: MM

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About This Item

经验公式（希尔记法）:

C₂₀H₂₄O₆

CAS Number:

38748-32-2

分子量:

360.40

MDL编号:

MFCD00210565

UNSPSC代码:

12352200

NACRES:

NA.77

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Product Name

Triptolide, Tripterygium wilfordii, A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

质量水平

100

描述

RTECS - YK7751000

方案

≥95% (HPLC)

表单

solid

制造商/商品名称

Calbiochem^®

储存条件

OK to freeze
protect from light

颜色

off-white

溶解性

DMSO: 20 mg/mL

运输

ambient

储存温度

−20°C

SMILES字符串

O1[C@@]32[C@]5(O[C@H]5C[C@@H]6[C@@]3(CCC7=C6COC7=O)C)[C@@H]([C@]4(O[C@H]4[C@@H]21)C(C)C)O

InChI

1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI key

DFBIRQPKNDILPW-CIVMWXNOSA-N

一般描述

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).

生化/生理作用

Cell permeable: no

Primary Target
Activate DEVD-cleaving caspases

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

其他说明

Zhao, Q., et al. 2005. J. Biol. Chem.280, 8101.
Shepherd, E., et al. 2004. J. Biol. Chem.279, 54023.
Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
Yang, Y., et al. 1998. Immunopharmacology40, 139.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

象形图

GHS06,GHS08

警示用语：

Danger

危险声明

H300 + H330,H361f

预防措施声明

P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Repr. 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)