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经验公式(希尔记法):
C18H13F6N3O2S
化学文摘社编号:
分子量:
449.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C18H13F6N3O2S/c1-11-2-8-14(9-3-11)30(28,29)26-12-4-6-13(7-5-12)27-16(18(22,23)24)10-15(25-27)17(19,20)21/h2-10,26H,1H3
InChI key
CVALMMCIOLXHDM-UHFFFAOYSA-N
SMILES string
FC(F)(F)c1[n](nc(c1)C(F)(F)F)c2ccc(cc2)N[S](=O)(=O)c3ccc(cc3)C
assay
≥98% (HPLC)
form
semisolid
solid
potency
720 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
orange-brown
white to off-white
solubility
DMSO: 100 mg/mL
shipped in
wet ice
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TRPC3
TRPC3
Reversible: yes
Disclaimer
Toxicity: Standard Handling (A)
General description
A cell-permeable pyrazole derivative that acts as a selective blocker of the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) and inhibits Carbachol- (Cat. No. 212385) induced Ca2+ entry in TRPC3-expressing HEK293 cells (IC50 = 0.72 µM; by Fura-2), while exhibiting much reduced potency against Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 13.08 µM; by Fura-2). A great complement to Pyr2 (Cat. No. 203890), Pyr 3 (Cat. No. 648490), and Pyr6 (Cat. No. 203891) in Ca2+ signaling studies.
Other Notes
Schleifer, H. et al. 2012. Br. J. Pharmacol.167, 1712.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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