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Merck
CN

654380

Tunicamycin

from Strepomyces lysosuperficus, ≥98% (A+B+C+D, HPLC), powder, N-acetylglucosamine transferase, Calbiochem

别名:

衣霉素，来自链霉菌Streptomyces lysosuperficus

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关于此项目

经验公式（希尔记法）:
C39H64N4O16
化学文摘社编号:
11089-65-9
分子量:
844.94
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00065709

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产品名称

衣霉素，来自链霉菌Streptomyces lysosuperficus,

SMILES string

N4(C=CC(=O)NC4=O)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(O)C[C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)NC(=O)\C=C\CC(C)C)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3NC(=O)C)O)O)CO

InChI

1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1

InChI key

ZHSGGJXRNHWHRS-PEALBESXSA-N

description

Tunicamycin, Streptomyces lysosuperficus

assay

≥98% (A+B+C+D, HPLC)

form

powder

manufacturer/tradename

Calbiochem®

solubility

DMSO: 10 mg/mL
DMF: soluble
pyridine: soluble

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

相关类别

Biochem/physiol Actions

次要靶标
细胞中凝血酶诱导的Ca2+流通。
首要靶标
N-连接糖基化

Disclaimer

毒性：高毒性 & 致癌性/致畸性（I）

General description

一种可抑制N-连接糖基化并阻止N-糖苷蛋白-碳水化合物键形成的核苷抗生素。对革兰氏阳性细菌、酵母、真菌和病毒具有体外活性。抑制人类T淋巴母细胞上功能性凝血酶受体的表达。还可抑制细胞中凝血酶诱导的Ca2+流通。

Other Notes

Tordai, A., et al. 1995.Biochem.Biophys.Res. Commun.206, 857.
Price, B.D., et al. 1992.J. Cell Physiol.152, 545.
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Preparation Note

可通过在pH 8.0至10.0的H₂O中稀释或用pH >7.0的适当缓冲液从DMSO储备液中制备水溶液。
可通过在pH 8.0至10.0的H₂O中稀释或用pH >7.0（>8.0更好）的适当缓冲液从DMSO储备液中制备水溶液。
溶解后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定2周。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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