产品名称
AG490, InSolution, ≥98%, inhibitor of EGFR kinase autophosphorylation
assay
≥98% (HPLC)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−70°C
Quality Level
相关类别
Disclaimer
毒性：刺激性（B）
General description
表皮生长因子受体激酶自身磷酸化的有效抑制剂（IC50=100nm）。Jak家族酪氨酸激酶抑制剂。AG 490对Jak2的抑制通过诱导程序性细胞死亡，选择性地阻断体外和体内白血病细胞生长，对正常造血没有有害影响。抑制STAT-3和IL-2诱导的MF肿瘤细胞生长的组成性激活。AG 490也被证明能抑制JAK3的自激酶活性。据报道，还抑制鸟苷酸环化酶。
Other Notes
Jaleel, M., et al. 2004.Biochemistry43, 8247.
Eriksen, K.W., et al. 2001.Leukemia15, 787.
Kirken, R.A., et al. 1999.Leukoc.Biol.65, 891.
Nielsen, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 6764.
Meydan, N., et al. 1996.Nature 379, 645.
Gazit, A., et al. 1991.J. Med. Chem.34, 1896.
Levitzki, A. 1990.Biochem.Pharmacol.40, 913.
Eriksen, K.W., et al. 2001.Leukemia15, 787.
Kirken, R.A., et al. 1999.Leukoc.Biol.65, 891.
Nielsen, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 6764.
Meydan, N., et al. 1996.Nature 379, 645.
Gazit, A., et al. 1991.J. Med. Chem.34, 1896.
Levitzki, A. 1990.Biochem.Pharmacol.40, 913.
Packaging
用惰性气体包装
Physical form
100 mM (5 mg/170 µl)AG490的DMSO溶液（目录号658401）。
Preparation Note
初次解冻后，分装冻存（-70°C）。一旦打开，贮备溶液在-70°C下可稳定保存6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
188.6 °F - closed cup - (Dimethylsulfoxide)
flash_point_c
87 °C - closed cup - (Dimethylsulfoxide)
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