658452
AG 126
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
别名:
AG 126, α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
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关于此项目
经验公式（希尔记法）:
C10H5N3O3
化学文摘社编号:
分子量:
215.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 5 mg/mL, DMF: soluble
shipped in
ambient
storage temp.
−20°C
SMILES string
[N+](=O)([O-])c1c(cc(cc1)C=C(C#N)C#N)O
InChI
1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
InChI key
DUQADSPERJRQBW-UHFFFAOYSA-N
General description
A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC50 = 15.38 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-2 activity
COX-2 activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells
Other Notes
Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
存储类别
11 - Combustible Solids
wgk
WGK 3