662006
U0124
A useful negative control for MEK inhibitors U0125 and U0126.
别名:
U0124, 1,4-二氨基-2,3-二氰基-1,4-双(甲硫基)丁二烯
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关于此项目
经验公式（希尔记法）:
C8H10N4S2
化学文摘社编号:
分子量:
226.32
MDL number:
NACRES:
NA.77
UNSPSC Code:
12352200
产品名称
U0124, A useful negative control for MEK inhibitors U0125 and U0126.
form
solid
assay
≥95% (HPLC)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
相关类别
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Biochem/physiol Actions
主靶
MEK1
MEK1
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
Disclaimer
毒性：标准处理（A）
General description
MEK抑制剂U0125（目录号662008）和U0126（目录号662005）的有效阴性对照。即使在100µM的浓度下，也不会抑制MEK。
Other Notes
Favata, M.F., et al. 1998.J. Biol. Chem. 273, 18623.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C可稳定保存最多2周。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Katherine E Savell et al.
Science advances, 6(26), eaba4221-eaba4221 (2020-07-09)
Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter transcriptional programs believed to promote long-lasting synaptic and behavioral adaptations. Here, we leveraged single-nucleus RNA-sequencing to generate a comprehensive molecular atlas of cell subtypes in the NAc
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