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Merck
CN

662086

UCH-L1 Inhibitor

The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

别名:

UCH-L1 Inhibitor, LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor

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关于此项目

经验公式（希尔记法）:
C17H11Cl3N2O3
化学文摘社编号:
668467-91-2
分子量:
397.64
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09037562

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产品名称

UCH-L1 Inhibitor, The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

SMILES string

Clc1c(cc(cc1)Cl)CN2c3c(cc(cc3)Cl)\C(=N\OC(=O)C)\C2=O

InChI

1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

InChI key

OPQRFPHLZZPCCH-PGMHBOJBSA-N

assay

≥95% (HPLC)

form

solid

potency

0.88 μM IC50
0.40 μM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

Cell permeable: no
Primary Target
UCH-L1
Product competes with ATP.
Reversible: yes

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

A potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM; IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µM. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson′s disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type.
An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.

Other Notes

Liu, Y., et al. 2003. Chem. Biol.10, 837.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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