assay
≥95% (SDS-PAGE)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
Quality Level
General description
Full-length, recombinant, human UbcH5c expressed in E. coli. UbcH5c, an E2 ubiquitin ligase, is highly homologous to the yeast UbC4/5 family of E2 enzymes. UbcH5c, together with UbcH5a and UbcH5b, are the most active class of E2 enzymes in cell extracts and are associated with regulation of transcription factors such as p53, NF-κB3, and c-Fos. The active enzyme is useful in the study of ubiquitin regulation and inhibitor screening.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 50 mM HEPES, 50 mM NaCl, 1 mM DTT, 10% glycerol, pH 7.0.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Brzovic, P.S., et al. 2006. Cell Cycle5, 2867.
Gehrke, S.G., et al. 2003 Blood.101, 3288.
Nuber, U., And Scheffner, M., 1999. J. Biol. Chem.274, 7576.
Schwarz, S.E., et al. 1998. J. Biol. Chem.273, 12148.
Jensen, J., et al. 1995. J. Biol. Chem.270, 30408.
Scheffner, M., et al. 1994. Proc. Natl. Acad. Sci.91, 8797.
Gehrke, S.G., et al. 2003 Blood.101, 3288.
Nuber, U., And Scheffner, M., 1999. J. Biol. Chem.274, 7576.
Schwarz, S.E., et al. 1998. J. Biol. Chem.273, 12148.
Jensen, J., et al. 1995. J. Biol. Chem.270, 30408.
Scheffner, M., et al. 1994. Proc. Natl. Acad. Sci.91, 8797.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
Kei Miyakawa et al.
Nature communications, 13(1), 531-531 (2022-01-29)
Autophagy has been linked to a wide range of functions, including a degradative process that defends host cells against pathogens. Although the involvement of autophagy in HBV infection has become apparent, it remains unknown whether selective autophagy plays a critical
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