662105
PYR-41
≥90% (sum of two isomers, HPLC), Ubiquitin E1 Inhibitor, solid
别名:
泛素E1抑制剂，PYR-41, 4-(4-(5-硝基-呋喃-2-基亚甲基)-3,5-二氧代-吡唑烷-1-基)-苯甲酸乙酯，三水合物，泛素活化酶E1抑制剂，PYR-41
产品名称
泛素E1抑制剂，PYR-41, The Ubiquitin E1 Inhibitor, PYR-41 controls the biological activity of Ubiquitin E1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
assay
≥90% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
dark purple
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
Quality Level
Disclaimer
毒性：刺激性（B）
General description
一种细胞渗透性吡唑酮化合物，不可逆地（可能通过共价修饰）抑制泛素激活酶E1活性（无细胞E1泛素化反应中的IC50<10 µM），同时对E3、E2或半胱天冬酶活性表现出很少或没有活性。阻断泛素化依赖的蛋白质降解和其他泛素化介导的细胞活动。已显示，通过PYR-41或其他方式使E1失活可导致苏素化的总体升高。
Other Notes
Yang, Y., et al. 2007.Cancer Res.67, 9472.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多1个月。在室温下，化合物每天将经历约1%的分解。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Subhash Mehto et al.
The EMBO journal, 41(23), e111289-e111289 (2022-10-13)
The NOD1/2-RIPK2 is a key cytosolic signaling complex that activates NF-κB pro-inflammatory response against invading pathogens. However, uncontrolled NF-κB signaling can cause tissue damage leading to chronic diseases. The mechanisms by which the NODs-RIPK2-NF-κB innate immune axis is activated and
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