676380
Valproic Acid sodium salt
≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem®
别名:
丙戊酸钠盐, 2-丙基戊酸钠
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关于此项目
经验公式（希尔记法）:
C8H15NaO2
化学文摘社编号:
分子量:
166.19
UNSPSC Code:
12352106
NACRES:
NA.77
MDL number:
eCl@ss:
42020819
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic)
产品名称
丙戊酸钠盐, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC50 = 400 µM for HDAC1).
Quality Segment
description
Merck USA index - 14, 9913
assay
≥98% (HPLC)
form
solid
potency
400 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
color
white
solubility
water: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[Na+].[O-]C(=O)C(CCC)CCC
InChI
1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChI key
AEQFSUDEHCCHBT-UHFFFAOYSA-M
General description
一种细胞可渗透性短链脂肪酸，可抑制组蛋白脱乙酰酶活性（HDAC1的IC50 = 400 µM）。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平（350 µM-1.04 mM），引起肌醇耗竭，抑制GSK-3α和-3β，激活ERK通路，并产生神经营养效应。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体（PPAR）活性。在人类和啮齿动物模型中显示出强效的致畸活性。
Biochem/physiol Actions
主要靶标
HDAC1
HDAC1
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Packaging
用惰性气体包装
Other Notes
Gottlicher, M., et al. 2001.EMBO J.20, 6969.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害 & 致癌/致畸性（E）
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable