Merck
CN
所有图片(1)

676380

Sigma-Aldrich

丙戊酸钠盐

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).

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别名:
丙戊酸钠盐, 2-丙基戊酸钠
Empirical Formula (Hill Notation):
C8H15NaO2
CAS号:
分子量:
166.19
MDL编号:
NACRES:
NA.77

质量水平

检测方案

≥98% (HPLC)

形式

solid

效能

400 μM IC50

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
desiccated (hygroscopic)

颜色

white

溶解性

water: 50 mg/mL

运输

ambient

储存温度

2-8°C

InChI

1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

InChI key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

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此商品
P4543567430PHR1061
Valproic Acid, Sodium Salt A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).

Sigma-Aldrich

676380

丙戊酸钠盐

Valproic acid sodium salt 98%

Sigma-Aldrich

P4543

丙戊酸 钠盐

Sodium Butyrate A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway.

Sigma-Aldrich

567430

丁酸钠

Valproic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1061

丙戊酸

form

solid

form

powder

form

solid

form

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic)

storage condition

-

color

white

color

-

color

white

color

-

solubility

water: 50 mg/mL

solubility

H2O: 50 mg/mL

solubility

water: 2 mg/mL

solubility

-

一般描述

一种细胞可渗透性短链脂肪酸,可抑制组蛋白脱乙酰酶活性(HDAC1的IC50 = 400 µM)。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平(350 µM-1.04 mM),引起肌醇耗竭,抑制GSK-3α和-3β,激活ERK通路,并产生神经营养效应。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体(PPAR)活性。在人类和啮齿动物模型中显示出强效的致畸活性。
一种细胞渗透性短链脂肪酸,可抑制组蛋白脱乙酰酶(HDAC1的IC50 = 400 µM)。诱导分化并抑制来源于人类恶性胶质瘤的细胞系的增殖。在治疗水平(0.35 mM-1.04 mM),引起肌醇耗竭,抑制GSK-3α和-3β,激活ERK通路并产生神经营养作用。已被用作抗癫痫药。也有报告刺激过氧化物酶体增殖物激活受体(PPAR)活性。在人类和啮齿动物模型中显示出强效的致畸活性。

生化/生理作用

主要靶标
HDAC1
产物不与ATP竞争。
可逆:否
细胞可渗透性:是

包装

用惰性气体包装

警告

毒性:有害 & 致癌/致畸性(E)

其他说明

Gottlicher, M., et al. 2001.EMBO J.20, 6969.
Knupfer, M.M., et al. 2001.Anticancer Res.21, 347.
Phiel, C.J., et al. 2001.J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001.J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001.J. Biol. Chem.276, 31674.
Chen, G., et al. 1999.J. Neurochem.72, 1327.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Repr. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function. Dysregulation of 3R:4R ratio causes tauopathy, and human neurons that recapitulate tau isoforms in
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