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Merck
CN

676500-M

VEGFR2/Flt3/c-Kit Inhibitor

≥97% (HPLC), VEGFR2/Flt3/c-Kit/KDR Inhibitor, solid

别名:

VEGFR2/Flt3/c-Kit Inhibitor, N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII, c-Kit Inhibitor I, Vascular Endothelial Growth Factor Receptor-2/Flt3/c-Kit Inhibitor, N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-Nʹ-(3-methylphenyl)urea, Flt-3 Inhibitor V, VEGFR Tyrosine Kinase Inhibitor XXV, VEGFR2 Kinase Inhibitor XXII, c-Kit Inhibitor I

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关于此项目

经验公式（希尔记法）:
C21H19N5O
化学文摘社编号:
796967-10-7
分子量:
357.41
MDL number:
MFCD29090038
UNSPSC Code:
12352200
NACRES:
NA.77

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产品名称

VEGFR2/Flt3/c-Kit Inhibitor, The VEGFR2/Flt3/c-Kit Inhibitor, also referenced under CAS 796967-10-7, controls the biological activity of VEGFR2/Flt3/c-Kit. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

color

off-white

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

solubility

ethanol: 10 mg/mL, DMSO: 100 mg/mL

Quality Level

100

相关类别

General description

A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 µM•h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Dai, Y., et al. 2007. J. Med. Chem.50, 1584.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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