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关于此项目
经验公式(希尔记法):
C46H58N4O9 · xH2SO4
化学文摘社编号:
分子量:
810.97 (free base basis)
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
crystalline solid
Quality level:
Storage condition:
OK to freeze, desiccated, protect from light
Quality Level
description
Merck USA index - 14, 9982
assay
≥98% (HPLC)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
water: 50 mg/mL
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(O)O.N21C[C@H](C[C@@](C2)(O)CC)C[C@@](c8[nH]c9c(c8CC1)cccc9)(c3cc4c(cc3OC)N([C@@H]5[C@]64[C@H]7N(CC6)CC=C[C@]7([C@H]([C@]5(O)C(=O)OC)OC(=O)C)CC)C)C(=O)OC
InChI
1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
InChI key
KDQAABAKXDWYSZ-JKDPCDLQSA-N
General description
Antitumor alkaloid drug. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Affects interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2. Depolymerizes microtubules. Increases the frequency of micronucleated erythrocytes.
Biochem/physiol Actions
Primary Target
Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
Interaction of tubulin with microtubule-associated proteins, specifically Tau and MAP2
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Tanaka, E., et al. 1995. J. Cell. Biol.128, 139.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 374.
Smith, C.D., et al. 1994. Cancer Lett.79, 213.
Smith, C.D., et al. 1994. Cancer Res.54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res.280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem.11, 509.
Boscoboinik, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 374.
Smith, C.D., et al. 1994. Cancer Lett.79, 213.
Smith, C.D., et al. 1994. Cancer Res.54, 3779.
Tsukidate, K., et al. 1993. Am. J. Pathol. 143, 198.
Jagetia, G.C., and Jacob, P.S. 1992. Mutat. Res.280, 87.
Jordan, M.A., et al. 1992. J. Cell Sci. 102, 401.
Prasad, V., et al. 1992. J. Protein Chem.11, 509.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Muta. 2 - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 677175-10MG | 04055977260595 |

