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Merck
CN
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About This Item

经验公式(希尔记法):
C16H15N3O3
CAS Number:
分子量:
297.31
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

solid

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

pale yellow

溶解性

DMSO: 50 mg/mL

运输

ambient

储存温度

2-8°C

SMILES字符串

N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC

InChI

1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)

InChI key

BNDYIYYKEIXHNK-UHFFFAOYSA-N

一般描述

A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.

生化/生理作用

Cell permeable: no
Primary Target
Cdk2
Product does not compete with ATP.
Reversible: no
Target IC50: 1 µM for Cdk2

包装

Packaged under inert gas

制备说明

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Toxicity: Standard Handling (A)

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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