681500
WHI-P180
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.
别名:
WHI-P180, 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline
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关于此项目
经验公式（希尔记法）:
C16H15N3O3
化学文摘社编号:
分子量:
297.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC
InChI
1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
InChI key
BNDYIYYKEIXHNK-UHFFFAOYSA-N
General description
A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Cdk2
Cdk2
Product does not compete with ATP.
Reversible: no
Target IC50: 1 µM for Cdk2
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable