681525
Wiskostatin
A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly.
别名:
Wiskostatin
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关于此项目
经验公式（希尔记法）:
C17H18Br2N2O
化学文摘社编号:
分子量:
426.15
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Brc1cc2c([n](c3c2cc(cc3)Br)CC(O)CN(C)C)cc1
InChI
1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
InChI key
XUBJEDZHBUPBKL-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
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General description
A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
N-WASP (neural Wiskott Aldrich syndrome protein)
N-WASP (neural Wiskott Aldrich syndrome protein)
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol.11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol.9, 1275.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol.9, 1275.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
signalword
Danger
hcodes
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
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