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681636-M

W-13, Hydrochloride

Name: W-13, Hydrochloride
Brand: MM

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

别名:

W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₇ClN₂O₂S · xHCl

化学文摘社编号:

88519-57-7

分子量:

312.81 (free base basis)

UNSPSC Code:

12352200

MDL number:

MFCD00058030

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 35 mg/mL

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NCCCCN)c1cc2c(c(ccc2)Cl)cc1.Cl

InChI

1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H

InChI key

QKAALLVQBOLELJ-UHFFFAOYSA-N

说明

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM) and myosin light chain kinase (IC₅₀ = 58 µM).

Biochem/physiol Actions

Target IC₅₀: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

Analysis Note

single spot by TLC

Other Notes

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c