681636-M
W-13, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).
别名:
W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
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关于此项目
经验公式（希尔记法）:
C14H17ClN2O2S · xHCl
化学文摘社编号:
分子量:
312.81 (free base basis)
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
SMILES string
[S](=O)(=O)(NCCCCN)c1cc2c(c(ccc2)Cl)cc1.Cl
InChI
1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
InChI key
QKAALLVQBOLELJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
white
solubility
water: 35 mg/mL
Quality Level
storage temp.
2-8°C
General description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).
Biochem/physiol Actions
Target IC50: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase
Analysis Note
single spot by TLC
Other Notes
Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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