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681660-M

N-WASP-Inhibitor, 187-1

Name: N-WASP-Inhibitor, 187-1
Brand: MM

The N-WASP-Inhibitor, 187-1 controls the biological activity of neural Wiskott Aldrich syndrome protein (N-WASP). This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

N-WASP-Inhibitor, 187-1, cyclo( LK DF DP DF LF DP LQ)₂

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关于此项目

经验公式（希尔记法）:

C₉₆H₁₂₂N₁₈O₁₆

分子量:

1784.11

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic)

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属性

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

DMSO: 1 mg/mL, acetic acid: 5%

storage temp.

−20°C

说明

General description

A 14-amino acid cyclic peptide that potently blocks phosphatidylinositol 4,5-bisphosphate (PIP₂)-induced actin assembly in Xenopus egg cytoplasmic extract (IC₅₀ ~2 µM). Shown to directly bind to neural Wiskott Aldrich syndrome protein (N-WASP) with high-affinity, and allosterically stabilize the autoinhibited conformation of N-WASP. It prevents the activation of actin-related protein 2/3 (Arp2/3) complex by blocking the interaction between N-WASP and Arp2/3.

Biochem/physiol Actions

Primary Target
Neural Wiskott Aldrich syndrome protein (N-WASP)

Target IC₅₀: ~ 2 µM blocking phosphatidylinositol 4,5-bisphosphate (PIP2)-induced actin assembly in Xenopus egg cytoplasmic extract

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Peterson, J.R., et al. 2001. Proc. Natl. Acad. Sci. USA98, 10624.
Suetsugu, S., et al. 2001. J. Biol. Chem.276, 33175.

cyclo(LLys-DPhe-DPro-DPhe-LPhe-DPro-LGln)₂

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c