681671
IWP-2
≥97% (HPLC), solid, Wnt antagonist, Calbiochem
别名:
Wnt拮抗剂II，IWP-2, Wnt 生P产抑制剂-2，Wnt通路抑制剂II，Porcn抑制剂I
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关于此项目
经验公式（希尔记法）:
C22H18N4O2S3
化学文摘社编号:
分子量:
466.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Wnt拮抗剂II，IWP-2, The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
SMILES string
[s]1c2c(nc1NC(=O)CSc3[n]([c](c5c(n3)CCS5)=O)c4ccccc4)ccc(c2)C
InChI
1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChI key
WRKPZSMRWPJJDH-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 2.5 mg/mL
shipped in
ambient
Quality Level
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相关类别
General description
一种细胞渗透性苯并噻唑基乙酰胺化合物，通过选择性阻断MBOAT（膜结合O-酰基转移酶）家族成员Porcn-（Porcupine）介导的Wnt棕榈酰化作用抑制细胞Wnt加工和分泌。IWP-2一般不影响Wnt/β-连环蛋白信号通路，与IWR-1-endo（目录号681669）不同，IWP-2对Wnt刺激的细胞反应没有影响。
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Other Notes
Chen, B., et al. 2009.Nature Chem. Biol.5, 100.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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