681671
IWP-2
≥97% (HPLC), solid, Wnt antagonist, Calbiochem
别名:
Wnt拮抗剂II，IWP-2, Wnt 生P产抑制剂-2，Wnt通路抑制剂II，Porcn抑制剂I
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关于此项目
经验公式（希尔记法）:
C22H18N4O2S3
化学文摘社编号:
分子量:
466.60
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Wnt拮抗剂II，IWP-2, The Wnt Antagonist II, IWP-2, also referenced under CAS 686770-61-6, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
SMILES string
[s]1c2c(nc1NC(=O)CSc3[n]([c](c5c(n3)CCS5)=O)c4ccccc4)ccc(c2)C
InChI
1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)
InChI key
WRKPZSMRWPJJDH-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 2.5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Disclaimer
毒性：有害（C）
General description
一种细胞渗透性苯并噻唑基乙酰胺化合物，通过选择性阻断MBOAT（膜结合O-酰基转移酶）家族成员Porcn-（Porcupine）介导的Wnt棕榈酰化作用抑制细胞Wnt加工和分泌。IWP-2一般不影响Wnt/β-连环蛋白信号通路，与IWR-1-endo（目录号681669）不同，IWP-2对Wnt刺激的细胞反应没有影响。
Other Notes
Chen, B., et al. 2009.Nature Chem. Biol.5, 100.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Following implantation, the naive pluripotent epiblast of the mouse blastocyst generates a rosette, undergoes lumenogenesis and forms the primed pluripotent egg cylinder, which is able to generate the embryonic tissues. How pluripotency progression and morphogenesis are linked and whether intermediate
Yuan Gao et al.
Journal of pain research, 13, 1049-1058 (2020-06-18)
The upregulation of spinal NMDA receptor is a crucial mechanism in remifentanil-induced hyperalgesia (RIH). Wnt3a/β-catenin pathway plays an important role in neuropathic pain. We hypothesized that wnt3a inhibitor (iwp-2) could downregulate the expression of NR2B subunit in NMDA receptor, in
Eirini Kyriakopoulou et al.
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Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 (PKP2) is the most frequently affected gene. Here we show that adeno-associated virus (AAV)-mediated delivery of PKP2 in
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