692000
ZM 336372
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM).
别名:
ZM 336372, N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
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关于此项目
经验公式（希尔记法）:
C23H23N3O3
化学文摘社编号:
分子量:
389.45
UNSPSC Code:
12352117
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O
InChI
1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChI key
PYEFPDQFAZNXLI-UHFFFAOYSA-N
General description
A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Protein kinase c-Raf
Protein kinase c-Raf
Product competes with ATP.
Reversible: yes
Target IC50: 70 nM against protein kinase c-Raf
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Other Notes
Hall-Jackson, C.A., et al. 1999. Chem. Biol.6, 559.
Legal Information
Sold under license of PCT Application W098/22,103.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 4 - Skin Sens. 1B
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable