Hydroxylamine NovaTag resin is an ideal tool for the synthesis of peptides labeled at the C-terminus with an hydroxylamine group. Such peptides readily undergo oxime formation in aqueous media with aldehyde-modified proteins or peptides, MAP core peptides, or surfaces. For the synthesis of MAPs, this approach avoids many of the problems associated with their purification and analysis, since the linear peptide antigen can be fully characterized prior to conjugation with the pre-formed lysine tree.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.20 - 0.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh

Replaces: 04-12-3909

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany