8.55094
Trichloroacetimidate Wang resin
Novabiochem®
别名:
Trichloroacetimidate Wang resin
SMILES string
ClC(Cl)(Cl)C(=N)OCc1ccc(cc1)OC
InChI
1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
InChI key
TYHGKLBJBHACOI-UHFFFAOYSA-N
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
General description
A highly versatile reagent for the solid phase immobilization of alcohols [1,2,3]; carboxylic, phosphonic and sulfonic acids [4]; thiols and thioacids [4]; and phenols [5]. In contrast to the analogous bromide resin which is loaded under basic conditions, derivatization of this support is achieved under acidic conditions, making it compatible with base-sensitive compounds such as Fmoc-amino alcohols.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] S. Hanessian & X. Fang (1998) Tetrahedron Lett., 39, 733.
[2] A. Bianco, et al. (2000) J. Comb. Chem., 2, 681.
[3] A. Kamal, et al. (2002) Tetrahedron Lett., 43, 2103.
[4] C. W. Phoon, et al. (1998) Tetrahedron Lett., 39, 7959.
[5] A. Kamal, et al. (2001) Tetrahedron Lett., 42, 6969.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] S. Hanessian & X. Fang (1998) Tetrahedron Lett., 39, 733.
[2] A. Bianco, et al. (2000) J. Comb. Chem., 2, 681.
[3] A. Kamal, et al. (2002) Tetrahedron Lett., 43, 2103.
[4] C. W. Phoon, et al. (1998) Tetrahedron Lett., 39, 7959.
[5] A. Kamal, et al. (2001) Tetrahedron Lett., 42, 6969.
Analysis Note
Color (visual): slight yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis after derivatization with thioacetic acid): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh
Appearance of substance (visual): beads
Loading (determined by elemental analysis after derivatization with thioacetic acid): 0.60 - 1.20 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh
Other Notes
Replaces: 01-64-0314
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持