NovaSyn^® TG PAP RESIN

NovaSyn TG PAP resin contains an acid cleavable linkage between the polystyrene matrix and the PEG chain. Treatment of peptides prepared on this resin with TFA/thioanisole (95:5) for 12 hours or TMSBr/TFA/thioanisole (1:94:5) for 60 minutes releases a fully deprotected peptide possessing a PEG-chain attached to the C-terminus ^[1]. Such peptide-PEG conjugates can be used directly as immunogens, without the need for a carrier protein. The peptide-PEG conjugates are also highly soluble and provide an effective solution to insoluble peptides.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references

^[1] W. Rapp in ′Combinatorial Peptide and Nonpeptide Libraries′, G. Jung (Eds), Vch, 1996, pp. 425.

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.20 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany