The developmentally-regulated neuron-specific protein, Drebrin A, is expressed first at the time of outgrowth and maturation of dendrites, and is localized within dendrites of the adult brain. Drebrin E+A- signals have been observed in the cell bodies of migrating neuroblasts in the core region; however, only fibrous and punctate drebrin E+A- signals were observed in postmigratory neuroblasts at the outer layers. Studies have demonstrated that the disappearance of drebrin E+A- signals from the cell body coincides with the cessation of neuronal migration. The disappearance of drebrin E from the cell body may be a molecular switch for the cessation of migration in newly generated neuroblast

Cat. # AB10140 detects the internal domain of Drebrin A/E.

May react with human based on sequence homology. Reactivity with other species has not been determined.

Epitope: Internal Domain

KLH conjugated synthetic linear peptide.

Detect Drebrin A/E using this Anti-Drebrin A/E Antibody validated for use in WB & IC.

Immunocytochemistry: Proven to react with Drebrin A/E in 16 DIV rat cortical neurons. Photo courtesy of Dr. Gang Lui, Drexel University.

Research Category
Neuroscience

Research Sub Category
Synapse & Synaptic Biology

Western Blot:
A 1:5,000 dilution of this antibody was used to detect embryonic rat brain (day 16) tissue lysate.

~77 kDa

Antigen Affinity Purified

Purified rabbit polyclonal antibody in PBS with 0.05% NaN3.

Stable for 1 year at 2-8ºC from date of receipt.

Control
Embryonic rat brain (day 16) tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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