AB1254
抗细胞色素P450酶CYP3A4抗体
serum, Chemicon®
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human, pig
Citations:
21
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗细胞色素P450酶CYP3A4抗体, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, pig
species reactivity (predicted by homology)
mammals, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CYP3A4(1576)
Analysis Note
对照
肝组织
肝组织
Application
抗细胞色素P450酶CYP3A4抗体可检测细胞色素P450酶CYP3A4水平 & 已出版 & 经过验证可用于IH & WB。
研究子类别
酶&生物化学
酶&生物化学
研究类别
代谢
代谢
蛋白质印迹： 1:1000-1:2000：使用微粒体膜级分，检测~54 kDa的条带；也可能存在其他条带。 抗体已成功用于LICOR荧光westerns检测CYP3A4。
免疫组化：10%福尔马林固定，石蜡包埋的组织1:200-1:400，建议使用微波-柠檬酸抗原回收。
最佳工作稀释度必须由最终用户确定。
免疫组化：10%福尔马林固定，石蜡包埋的组织1:200-1:400，建议使用微波-柠檬酸抗原回收。
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
兔多克隆血清检测人和大鼠体内CYP3A4；通过所用免疫原的序列同源性，可以预期与CYP3A7、3A6V4；3A2V1、3A8、3A9的交叉反应性，但此时尚未测试。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
57 kDa
Immunogen
含有来自人CYP3A4的TVSGA的C端序列的合成肽。该肽与KLH偶联。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
兔抗血清。 不含防腐剂的液体。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Manuel Vlach et al.
Sensors (Basel, Switzerland), 19(10) (2019-05-18)
Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In this work, we
Nicolas Quesnot et al.
Archives of toxicology, 92(10), 3077-3091 (2018-08-29)
CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived glucuronide appears
Ulrik Kræmer Sundekilde et al.
Toxicology, 469, 153121-153121 (2022-02-11)
The circadian rhythm has profound effect on the body, exerting effects on diverse events like sleep-wake patterns, eating behavior and hepatic detoxification. The cytochrome p450 s (Cyps) is the main group of enzymes responsible for detoxification. However, the underlying mechanisms
Els Van Peer et al.
Basic & clinical pharmacology & toxicology, 114(5), 387-394 (2013-11-15)
Despite the increasing use of the minipig as a non-rodent species in general and juvenile toxicity studies, knowledge on their biotransformation processes and their ontogeny is scarce. Such data are prerequisite for the correct interpretation of non-clinical studies in this
Konstantin Neukirch et al.
Journal of medicinal chemistry, 64(15), 11496-11526 (2021-07-20)
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (27a), which allosterically inhibits 5-LOX, being
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