AB1566
抗物质P抗体，疼痛
serum, Chemicon®
别名:
Anti-Hs.2563, Anti-NK2, Anti-NKNA, Anti-NPK, Anti-TAC2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
radioimmunoassay
radioimmunoassay
Species reactivity:
human, mouse, rat
Citations:
55
Technique(s):
immunohistochemistry: suitable (paraffin)
radioimmunoassay: suitable
radioimmunoassay: suitable
Uniprot accession no.:
产品名称
抗物质P抗体，疼痛, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable (paraffin)
radioimmunoassay: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TAC1(6863)
Analysis Note
免疫组织化学（石蜡）：
物质P（AB1566）在阿尔茨海默氏症’脑中的代表性染色模式/形态。 用枸橼酸盐pH6.0预处理，抗原修复的组织。抗体稀释至1:100。
IHC-石蜡染色枸橼酸（pH 6.0）表位修复：阿尔茨海默氏症’大脑。
物质P（AB1566）在阿尔茨海默氏症’脑中的代表性染色模式/形态。 用枸橼酸盐pH6.0预处理，抗原修复的组织。抗体稀释至1:100。
IHC-石蜡染色枸橼酸（pH 6.0）表位修复：阿尔茨海默氏症’大脑。
对照
脊髓。
脊髓。
Application
RIA：
先前批次的1:10,000稀释液已用于放射免疫测定。80%结合至少可检测到5 pg/mL。
最佳工作稀释度必须由最终用户进行确定。
先前批次的1:10,000稀释液已用于放射免疫测定。80%结合至少可检测到5 pg/mL。
最佳工作稀释度必须由最终用户进行确定。
研究子类别
神经炎症& 疼痛
神经炎症& 疼痛
研究类别
神经科学
神经科学
该抗物质P抗体，疼痛经过验证可用在IH(P)、RIA中检测物质P。
Biochem/physiol Actions
物质P
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
物质P是一种速激肽家族神经肽，起神经递质和神经调节剂的作用。在中枢神经系统中，物质P参与情绪、焦虑、睡眠、镇静、强化、呼吸节律和疼痛处理的调节。在伤害感受中，神经肽在局部脊髓突触处释放。最近的研究表明，物质P可能参与内皮细胞的分化，并在神经炎症反应中发挥多种作用。 物质P的内源性受体是神经激肽1受体（NK1受体），它属于GPCR的速激肽受体亚家族。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
含0.1%叠氮化钠的兔多克隆血清。
未纯化
Preparation Note
自收到之日起在-20ºC可稳定保存1年。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Aristea Sideri et al.
Cellular and molecular gastroenterology and hepatology, 1(4), 420-432 (2015-11-07)
Substance P (SP), neurokinin-1 receptors (NK-1Rs) are expressed in mesenteric preadipocytes and SP binding activates proinflammatory signalling in these cells. We evaluated the expression levels of SP (Tac-1), NK-1R (Tacr-1), and NK-2R (Tacr-2) mRNA in preadipocytes isolated from patients with
Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium.
Weidler, C; Holzer, C; Harbuz, M; Hofbauer, R; Angele, P; Scholmerich, J; Straub, RH
Annals of the Rheumatic Diseases null
Sai Y Veruva et al.
Clinical orthopaedics and related research, 475(5), 1369-1381 (2016-08-05)
The pathophysiology and mechanisms driving the generation of unintended pain after total disc replacement (TDR) remain unexplored. Ultrahigh-molecular-weight polyethylene (UHMWPE) wear debris from TDRs is known to induce inflammation, which may result in pain. The purpose of this study was
Yong Fang Zhu et al.
Molecular pain, 12 (2016-04-01)
Bone cancer pain is often severe, yet little is known about mechanisms generating this type of chronic pain. While previous studies have identified functional alterations in peripheral sensory neurons that correlate with bone tumours, none has provided direct evidence correlating
Andreas Hald et al.
European journal of pain (London, England), 13(2), 138-145 (2008-05-24)
Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury pain models and is thought to exacerbate pain perception. Following a nerve injury, a transient increase in the presence of microglia takes place while the increased
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