Anti-NIK Antibody, CT

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

Anti-NIK Antibody, C-terminus is an antibody against NIK for use in WB.

Research Category
Signaling

Research Sub Category
Cytoskeletal Signaling

Western blot

293 cell lysate can be used as positive control.

Optimal working dilutions must be determined by end user.

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kB activation by IL-1, TNFa and CD95 was identified recently and designated NIK (for NF-kB inducing kinase) (Malinin et al. 1997). NIK is an activator of IkB kinase alpha and beta (IKKalpha and IKKbeta) (Regnier et al. 1997; Woronicz et al. 1997; Ling et al. 1998; Nakano et al. 1998). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Epitope: C-terminus

Rabbit anti-NIK polyclonal antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK (Malinin et al. 1997).

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.