产品名称
DR5抗体，CT, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
mol wt
calculated mol wt-47.88 kDa
observed mol wt ~55 kDa
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TNFRSF10B(8795)
Application
DR5抗体（C端）可检测DR5水平 & 已发表 & 经验证可用于WB。
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
蛋白质印迹： 1:250至1:500
HeLa或K562细胞的全细胞裂解液可用作阳性对照。
最佳工作稀释度必须由最终用户进行确定。
HeLa或K562细胞的全细胞裂解液可用作阳性对照。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
细胞凋亡是由TNF家族中的某些细胞因子（包括TNF和Fas配体）通过其含有死亡结构域的受体诱导的。 TRAIL/Apo2L是TNF家族的新成员。 DR4最近被鉴定为TRAIL的受体。 最近，几个小组独立鉴定了一种含有TRAIL死亡结构域的新型受体，并将其命名为DR5、Apo2、TRAIL-R2、TRICK2或KILLER（Pan et al. 1997; Sheridan et al. 1997; Walczak et al. 1997; MacFarlane et al. 1997; Screaton et al. 1997; Wu et al. 1997; Chaudhary et al. 1997）。 与DR4一样，DR5转录本在正常组织和多种肿瘤细胞中广泛表达。 DR5与TRAIL结合，并介导TRAIL诱导的细胞死亡。 DR5过表达诱导细胞凋亡并激活NF-kB。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
表位：C端
针对对应于人DR5前体氨基酸388-407的肽产生的多克隆抗体（Pan et al. 1997; Sheridan et al. 1997）。
Other Notes
Physical form
亲和纯化的免疫球蛋白。 含0.02%叠氮化钠的PBS液体。
形式：纯化
Preparation Note
以未稀释的等分形式可在2-8°C冷藏保存长达12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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