Merck
CN
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文件

AB1766

Sigma-Aldrich

Anti-Dopamine Transporter Antibody, CT

Chemicon®, from rabbit

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别名:
DAT
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

affinity purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

monkey, human

制造商/商品名称

Chemicon®

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

NM_001044.3

UniProt登记号

Q01959

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

human ... SLC6A3(6531)

特异性

Dopamine Transporter (DAT), C-terminal.

免疫原

Synthetic peptide from the intracellular C-terminal region of human dopamine transporter (CEKDRELVDRGEVRQFTLRHWL).

应用

Anti-Dopamine Transporter Antibody, C-terminus detects level of Dopamine Transporter & has been published & validated for use in IH & WB.
Immunoblotting: 0.1-1.0 μg/mL. The antibody recognizes the ~88 kDa DAT protein in Western blot of human strial samples.
Immunohistochemistry using formaldehyde-fixed brain sections.
Not recommended for use on rodent.
Optimal working dilutions must be determined by the end user.

外形

Affinity purified immunoglobulin. Liquid in 100 μL of 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

储存及稳定性

Maintain at -20 to -80°C in undiluted aliquots for up to six months after date of receipt. Avoid repeated freeze-thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Zuzanna Kurowska et al.
Journal of Parkinson's disease, 1(1), 83-92 (2011-01-01)
We demonstrate that grafted human fetal mesencephalic neurons can survive and extend axons for 22 years in the brain of a patient with Parkinson's disease (PD). In this patient, the overall survival and fiber outgrowth of the grafts were, however
Chiharu Sogawa et al.
PloS one, 5(8), e11945-e11945 (2010-08-12)
The transporters for dopamine (DAT) and norepinephrine (NET) are members of the Na+- and Cl--dependent neurotransmitter transporter family SLC6. There is a line of evidence that alternative splicing results in several isoforms of neurotransmitter transporters including NET. However, its relevance
Maged M Harraz et al.
Molecular psychiatry, 26(2), 370-382 (2021-01-09)
Cocaine exerts its stimulant effect by inhibiting dopamine reuptake leading to increased dopamine signaling. This action is thought to reflect binding of cocaine to the dopamine transporter (DAT) to inhibit its function. However, cocaine is a relatively weak inhibitor of
Joanne Ng et al.
Science translational medicine, 13(594) (2021-05-21)
Most inherited neurodegenerative disorders are incurable, and often only palliative treatment is available. Precision medicine has great potential to address this unmet clinical need. We explored this paradigm in dopamine transporter deficiency syndrome (DTDS), caused by biallelic loss-of-function mutations in

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