AB2204
抗-BMAL1抗体
serum, from guinea pig
别名:
ARNT-like protein 1, brain and muscle, Basic-helix-loop-helix-PAS protein MOP3, Brain and muscle ARNT-like 1, member of PAS protein 3, aryl hydrocarbon receptor nuclear translocator-like, bHLH-PAS protein JAP3, basic-helix-loop-helix-PAS orphan MOP3 2, m
登录 查看组织和合同定价。
选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, human, rat
Citations:
8
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-BMAL1抗体, serum, from guinea pig
biological source
guinea pig
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ARNTL(406)
mouse ... Arntl(11865)
rat ... Arntl(29657)
Analysis Note
对C2C12组织裂解液进行常规检测
批次特定检测应用1：蛋白质印迹法
批次特定检测应用1：蛋白质印迹法
对照
C2C12组织裂解液
C2C12组织裂解液
Application
抗BMAL1抗体是用于WB的针对BMAL1的抗体。
研究子类别
昼夜节律 & 睡眠
昼夜节律 & 睡眠
研究类别
神经科学
神经科学
Biochem/physiol Actions
与其他物种的反应性尚未得到测试。
目录#AB2204将识别BMAL1的C端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
~69 kDa
脑和肌肉Arnt样蛋白-1（BMAL1；也称为MOP3或Arnt3）是一种转录因子，已知可调节昼夜节律。BMAL1是哺乳动物生物钟的唯一组成部分，其在小鼠模型中的唯一缺失会产生心律不齐。除了时钟缺陷外，这些BMAL1空小鼠还具有生殖问题，身材矮小，衰老快，并且患有进行性关节病，导致整体运动能力低于野生型小鼠。最近的表型数据表明，BMAL1及其伴侣时钟在调节葡萄糖稳态和代谢中也起作用。 最后，BMAL1、NPAS2和PER2与人类季节性情感障碍有关。 BMAL1转录是昼夜节律的，并受NR1D1（Rev-erb-alpha）和RORA的相互调节，后者在哺乳动物昼夜节律时钟中建立了第二个互锁环。
Immunogen
表位：C端
重组蛋白
Physical form
含0.05% NaN3的血清
Preparation Note
自收到之日起，在-20°C以未稀释的等分试样可保存1年。
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 1
Jeff R Jones et al.
Nature communications, 12(1), 5763-5763 (2021-10-03)
Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN entrains rhythms in the paraventricular nucleus (PVN) to time the daily release of corticosterone.
Karen J Tonsfeldt et al.
Journal of the Endocrine Society, 3(4), 716-733 (2019-03-25)
In rodents, the preovulatory LH surge is temporally gated, but the timing cue is unknown. Estrogen primes neurons in the anteroventral periventricular nucleus (AVPV) to secrete kisspeptin, which potently activates GnRH neurons to release GnRH, eliciting a surge of LH
Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus.
LeSauter, J; Lambert, CM; Robotham, MR; Model, Z; Silver, R; Weaver, DR
Testing null
Eric L Bittman
Methods in molecular biology (Clifton, N.J.), 2482, 191-210 (2022-05-25)
The mammalian suprachiasmatic nucleus (SCN) functions as a master circadian pacemaker. In order to examine mechanisms by which it keeps time, entrains to periodic environmental signals (zeitgebers), and regulates subordinate oscillators elsewhere in the brain and in the periphery, a
Yohei Kobayashi et al.
Neuron, 86(1), 264-275 (2015-03-25)
Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持