AB2963
抗MMP-3抗体，NT
from rabbit, purified by affinity chromatography
别名:
matrix metallopeptidase 3 (stromelysin 1, progelatinase), matrix metalloproteinase 3 (stromelysin 1, progelatinase), Matrix metalloproteinase-3, transin-1, proteoglycanase, stromelysin-1, Transin-13
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rhesus macaque, human
Citations:
4
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗MMP-3抗体，NT, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rhesus macaque, human
species reactivity (predicted by homology)
chimpanzee (100% sequence homology), rhesus monkey (100% sequence homology)
packaging
antibody small pack of 25 μg
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MMP3(4314)
Analysis Note
对照
经 PMA 处理的 HL-60 浓缩的培养基
经 PMA 处理的 HL-60 浓缩的培养基
通过蛋白质印迹在 PMA 处理的 HL-60 浓缩的培养基中进行了评估。
蛋白质印迹分析：0.1-1 µg/mL 的该抗体可在 10 µg PMA 处理的 HL-60 浓缩培养基中检测 MMP-3。
蛋白质印迹分析：0.1-1 µg/mL 的该抗体可在 10 µg PMA 处理的 HL-60 浓缩培养基中检测 MMP-3。
Application
使用该抗 MMP-3 抗体（N 末端，经过验证可用于 WB IH（P））-检测 MMP-3。
免疫组化分析：先前批次的抗体以 1：600 的稀释度在大肠癌和导管癌组织中检测到 MMP-3。
研究子类别
MMPs & TIMPs
MMPs & TIMPs
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
其他同源性：小鼠和大鼠（具有 64% 的序列同源性）。
该抗体识别 MMP-3 的 N 端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
MMP-3（基质金属蛋白酶 3），也称为基质溶酶 1，是锌内肽酶的基质金属蛋白酶（MMP）家族的成员。在胚胎发育、形态发生和组织重塑过程中，需要 MMP’s 去除细胞外基质机制。金属蛋白酶的内源性组织抑制剂（TIMPs）负责调节 MMP-3。该系统的任何破坏都可能导致关节炎、转移、动脉粥样硬化和肿瘤生长等疾病。
观测值〜58 kDa。
在 〜78 kDa 处可以观察到一个未表征的条带
在 〜78 kDa 处可以观察到一个未表征的条带
Immunogen
对应于人 MMP-3 N 末端 的 KLH 偶联的线性肽。
表位：N端
Other Notes
替代：AB812
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条下可稳定保存 1 年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A V Stone et al.
Osteoarthritis and cartilage, 23(10), 1780-1789 (2015-06-03)
Meniscus injury increases osteoarthritis risk but its pathobiology in osteoarthritis is unclear. We hypothesized that older adult vervet monkeys would exhibit knee osteoarthritic changes and the degenerative menisci from these animals would secrete matrix metalloproteinases (MMPs) and pro-inflammatory cytokines that
A V Stone et al.
Osteoarthritis and cartilage, 22(2), 264-274 (2013-12-10)
Meniscus injury increases the risk of osteoarthritis; however, the biologic mechanism remains unknown. We hypothesized that pro-inflammatory stimulation of meniscus would increase production of matrix-degrading enzymes, cytokines and chemokines which cause joint tissue destruction and could contribute to osteoarthritis development.
Alexis Rugamba et al.
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