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Merck
CN

AB3274

抗水通道蛋白2抗体

Chemicon®, from rabbit

别名:

AQP2, AQP-CD, WCD-CD

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗水通道蛋白2抗体, Chemicon®, from rabbit

biological source

rabbit

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... AQP2(359)

Analysis Note

对照
该抗体免费包含40 μg对照抗原(冻干粉)。用100 μL去离子水复溶。对于阴性对照,将0.5ug纯化蛋白与1 μg抗体在室温下预培养1小时。

最佳浓度必须由最终用户确定。

Application

抗水通道蛋白2抗体是一种用于WB,IH的针对水通道蛋白2的抗体。
研究子类别
离子通道 & 转运体
研究类别
神经科学
蛋白质印迹:1:200-1:1000,在大鼠肾膜上使用ECL。

大鼠肾脏切片上的免疫组化。

应使用载体蛋白如BSA(1-3%)进行稀释。

最佳工作稀释度必须由最终用户进行确定。

Biochem/physiol Actions

识别水通道蛋白2

物种反应性: 水通道蛋白2特异的表位在大鼠和小鼠中是相同的,而在人(17/18氨基酸)中仅略有不同。与其他物种的反应性尚未检验。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

Immunogen

高度纯化的肽对应于大鼠或小鼠水通道蛋白2的残基254-271(SwissProt登录号P34080)。

Other Notes

浓度:请参考批次特异性浓缩物的分析证书。

Physical form

亲和纯化的免疫球蛋白。 从含有1% BSA和0.05%叠氮化钠的pH7.4 PBS中进行冻干。用200 μL无菌蒸馏水复溶。使用前离心抗体制备(10,000 xg,5 min)。

Preparation Note

在接收之日起,将冻干物料在-20°C下保存长达6个月。复溶后以未稀释等分试样在 -20°C保存长达 6个月。应避免反复冻/融循环。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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hcodes

Hazard Classifications

Aquatic Chronic 3

存储类别

11 - Combustible Solids

wgk

WGK 3


分析证书(COA)

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Tanya M Gwathmey et al.
American journal of physiology. Renal physiology, 299(5), F983-F990 (2010-09-03)
The kidney is an important target for the actions of the renin-angiotensin system (RAS) and this tissue contains a complete local RAS that expresses the bioactive peptides angiotensin II (ANG II) and Ang-(1-7). We find both angiotensin type 1 (AT(1)R)
Stine Julie Tingskov et al.
Frontiers in physiology, 10, 948-948 (2019-08-27)
Arginine vasopressin (AVP) mediates water reabsorption in the kidney collecting ducts through regulation of aquaporin-2 (AQP2). Also, estrogen has been known to regulate AQP2. Consistently, we previously demonstrated that tamoxifen (TAM), a selective estrogen receptor modulator, attenuates the downregulation of
Sua Kim et al.
American journal of physiology. Renal physiology, 309(5), F474-F483 (2015-06-26)
Because cyclophosphamide-induced hyponatremia was reported to occur without changes in plasma vasopressin in a patient with central diabetes insipidus, we hypothesized that cyclophosphamide or its active metabolite, 4-hydroperoxycyclophosphamide (4-HC), may directly dysregulate the expression of water channels or sodium transporters
Sarah L Walton et al.
Clinical science (London, England : 1979), 134(23), 3213-3228 (2020-12-01)
Insulin-regulated aminopeptidase (IRAP), an enzyme that cleaves vasoactive peptides including oxytocin and vasopressin, is suggested to play a role in pregnancy and the onset of preeclampsia. Our aim was to examine the contribution of IRAP to arterial pressure regulation and
Carsten Rudat et al.
PloS one, 9(11), e112112-e112112 (2014-11-13)
The mesothelium, the lining of the coelomic cavities, and the urothelium, the inner lining of the urinary drainage system, are highly specialized epithelia that protect the underlying tissues from mechanical stress and seal them from the overlying fluid space. The

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