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Merck
CN

AB3598

Anti-Mitochondria Antibody

serum, Chemicon®

别名:

Anti-ACNINV3, Anti-FAD, Anti-PS-1, Anti-S182

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
6

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biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

monkey, human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, western blot: suitable

input

sample type neural stem cell(s)

NCBI accession no.

NM_000021.2

UniProt accession no.

P49768

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TOMM20L(387990)

General description

62 kDa
Presenilin 1 is a protein found in brain cells. Presenilin 1 has a major influence on the risk of contracting alzheimer′s disease. Its function is unknown. However, it may be involved in protein production and trafficking, especially during early development. More than 40 different mutations have been found in the presenilin 1 gene, and these mutations associate with early-onset familial alzheimer′s disease. Mutations in presenilin 1 tend to elevate levels of amyloid beta in the blood, cerebrospinal fluid, and brains of those affected by mutations

Immunogen

Presenilin 1 peptide conjugated to KLH.

Application

Anti-Mitochondria Antibody is an antibody against Mitochondria for use in WB & IC.
Immunoblotting: 1:500-1:1000

Immunocytochemistry: 1:100-1:300 on COS7, HeLa, 293 and SK-N-MC cell lines.

Optimal working dilutions must be determined by the end user.
Research Category
Stem Cell Research
Research Sub Category
Neural Stem Cells

Biochem/physiol Actions

Mitochondria. Recognizes a 62 kD protein of immunoblots of subcellular fractions enriched in mitochondrial fractions.



The antibody shows a moderate titer by ELISA to the immunogen peptide but does not immunoblot any expected presenilin 1 bands. Immunocytochemistry with the serum revealed a mitochondria-like staining that was still present after exhaustive preabsorption with the peptide. The staining co-localizes with CHEMICON′s anti-mitochondria antibody MAB1273.

Physical form

Rabbit serum preabsorbed against immunogen peptide. Liquid. Contains 0.01% sodium azide.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze-thaw cycles.

Analysis Note

Control
HeLa whole cell extract, human neuroblastoma SH-SY5Y cells

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

wgk

WGK 1

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Christopher L Yankaskas et al.
Nature biomedical engineering, 3(6), 452-465 (2019-05-08)
The challenge of predicting which patients with breast cancer will develop metastases leads to the overtreatment of patients with benign disease and to the inadequate treatment of aggressive cancers. Here, we report the development and testing of a microfluidic assay
Kang Chi et al.
Cell transplantation, 27(3), 456-470 (2018-05-15)
Parkinson's disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem cell therapies using cell replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although
Wei Wu et al.
Oncotarget, 7(16), 22819-22833 (2016-03-25)
Retinal pigment epithelium (RPE) transplantation is a particularly promising treatment of retinal degenerative diseases affecting RPE-photoreceptor complex. Embryonic stem cells (ESCs) provide an abundant donor source for RPE transplantation. Herein, we studied the time-course characteristics of RPE cells derived from
Yongwoo Yoon et al.
Stem cells (Dayton, Ohio), 38(8), 936-947 (2020-05-07)
Huntington's disease (HD) is a devastating, autosomal-dominant neurodegenerative disease, for which there are currently no disease-modifying therapies. Clinical trials to replace the damaged striatal medium spiny neurons (MSNs) have been attempted in the past two decades but have met with

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