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Merck
CN

AB3749

Anti-mGCM1 Antibody

from rabbit, purified by affinity chromatography

别名:

GCM motif protein 1, Glial cells missing homolog 1, chorion-specific transcription factor GCMa, glial cells missing homolog a

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

Anti-mGCM1 Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

input

sample type pancreatic stem cell(s)
sample type neural stem cell(s)

UniProt accession no.

P70348

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GCM1(8521)

Analysis Note

Routinely evaluated by western blot on HEK-293 lysates.

Western Blotting: Recommended working dilutions are 1:1000 – 1:2500.

Application

Research Category
Stem Cell Research
Research Sub Category
Neural Stem Cells
This Anti-mGCM1 Antibody is validated for use in WB for the detection of mGCM1.

Biochem/physiol Actions

Comparison of sequence homology suggests that this antibody will also react in mouse and rat; however, reactivity to other species has not been tested.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptided selected from the C-terminal region mouse GCM1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

50 kDa
GCM1 is a DNA binding protein with a GCM motif (glial cell missing motif) that is a key transcription factor for determining the fate of stem cells within the nervous system, in addition to being critical for placental development. This protein binds to the GCM motif (A/G)CCCGCAT, a novel sequence among known targets of DNA binding proteins. The N-terminal DNA-binding domain confers the unique DNA binding activity of this protein. Current studies indicate that the introduction of the mouse GCM1 gene in cultured cells from embryonic brains resulted in the induction of an astrocyte lineage.

Immunogen

Epitope: C-terminus
Synthetic GCM1 peptide, a.a. 401-418.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Peptide affinity purified
Purified rabbit polyclonal antibody in buffer containing PBS with 0.09% sodium azide.

Preparation Note

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Human Stem Cell Systems

As the focus of stem cell research undergoes a transition from animal to human models, researchers are in critical need of validated products to support the isolation, maintenance, differentiation, and characterization of human stem cells. While many reagents designed for rodent systems can be applied to human stem cell studies, they are not truly optimized for robust human stem cell culture or analysis. This is why human stem cell researchers have always trusted EMD Millipore, the first provider of commercially available human embryonic stem cells and human neural stem cell lines, to accelerate their research. All of our human stem cell systems are extensively tested in defined media culture, and differentiated progeny are comprehensively characterized with highly validated antibodies and detection reagents.

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