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AB5046P

Sigma-Aldrich

Anti-NMDAR1 Splice Variant C1 Antibody

Chemicon®, from rabbit

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eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

rat

包装

antibody small pack of 25 μg

制造商/商品名称

Chemicon®

技术

western blot: suitable

UniProt登记号

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

特异性

Specific for the NMDAR1 C1 splice variant. AB5046P recognizes the C1 splice insert present in NR1 variants, 1a, 1b, 3a and 3b. {Gorter et al, (1997), "The Role of Alternative Splicing of the NMDAR1 Receptor Subunit in Synaptic Plasticity" Chapter 4, pg 99, in The Ionotropic Glutamate Receptors , Monaghan, D.T. and Weinhold, R.J. (eds), Humana Press, New Jersey) By Western blot the antibody recognizes a protein with molecular weight of 100 kDa.

免疫原

Peptide corresponding to the C-terminus of the rat NMDAR1 C1 splice variant.

应用

Anti-NMDAR1 Splice Variant C1 Antibody is an antibody against NMDAR1 Splice Variant C1 for use in WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:1,000 using ECL on rat brain lysate.

Immunohistochemistry: 1:1,000.

Optimal working dilutions must be determined by the end user.

外形

Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM) so some residual salt may also be present. Reconstitute with 50 μL of PBS. Contains no preservatives.

储存及稳定性

Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

11 - Combustible Solids

WGK

WGK 1


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K D Holmes et al.
Journal of neurochemistry, 81(6), 1152-1165 (2002-06-18)
The N -methyl-D-aspartate receptor (NMDAR) is a multimeric transmembrane protein composed of at least two subunits. One subunit, NR1, is derived from a single gene and can be subdivided into three regions: the N-terminal extracellular domain, the transmembrane regions, and
Israel Pichardo-Casas et al.
Brain research, 1436, 20-33 (2011-12-27)
In recent years, microRNAs or miRNAs have been proposed to target neuronal mRNAs localized near the synapse, exerting a pivotal role in modulating local protein synthesis, and presumably affecting adaptive mechanisms such as synaptic plasticity. In the present study we
Fadia Ibrahim et al.
Cell reports, 3(2), 301-308 (2013-02-19)
RNA binding proteins (RBPs) have emerged as major causative agents of amyotrophic lateral sclerosis (ALS). To investigate the function of TAF15, an RBP recently implicated in ALS, we explored its target RNA repertoire in normal human brain and mouse neurons.
Pilar Sánchez-Blázquez et al.
The international journal of neuropsychopharmacology, 21(10), 938-948 (2018-06-04)
Several currently available animal models reproduce select behavioral facets of human mania as well as the abnormal glutamatergic neurotransmission and dysregulation of glycogen synthase kinase 3β that accompanies this disease. In this study, we addressed the therapeutic potential of ligands

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