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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
rat, guinea pig, mouse
Citations:
52
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗P物质受体抗体,疼痛, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat, guinea pig, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TAC1(6863)
Analysis Note
对照
脊髓,脑膜裂解物
脊髓,脑膜裂解物
已通过蛋白质印迹对小鼠脑膜裂解物进行了评估。
蛋白质印迹分析:
该抗体的1:500稀释液在10 μg小鼠脑膜裂解物中检测到NK-1R。
蛋白质印迹分析:
该抗体的1:500稀释液在10 μg小鼠脑膜裂解物中检测到NK-1R。
Application
免疫组化:
先前批次以1:100-1:1,000的稀释度使用。
蛋白质印迹分析:
先前批次以1:500的稀释度使用。
最佳工作稀释度必须由最终用户确定。
先前批次以1:100-1:1,000的稀释度使用。
蛋白质印迹分析:
先前批次以1:500的稀释度使用。
最佳工作稀释度必须由最终用户确定。
抗P物质受体抗体,疼痛可检测P物质受体水平&已发表,&经验证可用于IF,IH &WB。
研究子类别
神经炎症&疼痛
神经炎症&疼痛
研究类别
神经科学
神经科学
Biochem/physiol Actions
对P物质受体(NK-1)具有特异性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
35kda
P物质是一种速激肽家族神经肽,起神经递质和神经调节剂的作用。在CNS中,P物质参与情绪、焦虑、睡眠、镇静、强化、呼吸节律和疼痛处理的调节。在伤害感受中,神经肽在局部脊髓突触处释放。最近的研究表明,P物质可能参与内皮细胞的分化,并在神经炎症反应中发挥多种作用。 P物质的内源性受体是神经激肽1受体(NK1受体),它属于GPCR的速激肽受体亚家族。
Immunogen
一种与大鼠P物质受体(NK-1)的COOH末端23个氨基酸序列(385-407)相对应的合成肽。
表位:C末端
Other Notes
替代品:AB5800
浓度:请参考批次特异性浓缩物的分析证书。
Physical form
不含防腐剂的兔多克隆血清。
未纯化
Preparation Note
自收到之日起在-20ºC可稳定保存1年。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
L Sosulina et al.
Journal of neurophysiology, 114(4), 2500-2508 (2015-09-04)
Substance P (SP) is implicated in stress regulation and affective and anxiety-related behavior. Particularly high expression has been found in the main output region of the amygdala complex, the central amygdala (CE). Here we investigated the cellular mechanisms of SP
Terminal field and firing selectivity of cholecystokinin-expressing interneurons in the hippocampal CA3 area.
Lasztoczi, B; Tukker, JJ; Somogyi, P; Klausberger, T
The Journal of Neuroscience null
Yanyan Zhang et al.
International journal of oral science, 11(3), 24-24 (2019-09-11)
Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs). SGC activation is emerging as the key mechanism underlying inflammatory pain through
Marco Bocchio et al.
eNeuro, 3(5) (2016-11-09)
Unraveling the roles of distinct neuron types is a fundamental challenge to understanding brain function in health and disease. In the amygdala, a brain structure regulating emotional behavior, the diversity of GABAergic neurons has been only partially explored. We report
Wenling Chen et al.
Neuropharmacology, 128, 255-268 (2017-10-19)
The interaction between NMDA receptors and μ-opioid receptors in primary afferent terminals was studied by using NMDA to induce substance P release, measured as neurokinin 1 receptor internalization. In rat spinal cord slices, the μ-opioid receptor agonists morphine, DAMGO and
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