AB5312

抗生长相关蛋白43抗体

Name: 抗生长相关蛋白43抗体
Brand: MM

serum, Chemicon^®

别名:

GAP-43, Neuromodulin, B-50

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ICC, IHC (p), IP, WB

Citations:

主要文件

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biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, monkey, rat, feline, bovine

manufacturer/tradename

Chemicon^®

technique(s)

immunocytochemistry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, western blot: suitable

NCBI accession no.

NM_002045.2

UniProt accession no.

P17677

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GAP43(2596)

General description

23.6kda

GAP-43是分化神经元的常见标志物，在轴突生长过程中通过发育或再生神经元以升高的水平表达。尽管GAP-43是与轴突生长锥（和突触）的细胞质表面相关的完整膜蛋白，但树突状生长锥中却不存在。在成人大脑中，GAP-43在认为发生记忆形成的突触前区域（例如额叶皮层，边缘系统和海马）以高浓度发现。PKC（人，小鼠，大鼠和牛GAP-43上的Ser41或鸡和非洲爪蟾GAP-43上的Ser42）对GAP-43的磷酸化与某些形式的突触可塑性特别相关。

Immunogen

从猫脑中纯化GAP-43（McIntosh和Parkinson，1990）。

Application

免疫细胞化学：1:10 -1:400小鼠原代神经元，NTera2神经元。

免疫组织化学1:20 00成人视觉皮层冠状面切片（McIntosh和Parkinson, 1990）。AB5312已被用于小鼠嗅球4%多聚甲醛固定石蜡包埋组织切片的GAP-43染色（Legrier, 2001）。

蛋白质印迹：1:500 - 1:1,000。在成人视觉皮层蛋白提取物的蛋白质印迹上检测到约50 kDa的单个条带（McIntosh和Parkinson，1990）。

免疫沉淀

最佳工作稀释度必须由最终用户确定。

研究子类别
神经再生医学

信号神经科学

研究类别
神经科学

该抗生长相关蛋白43抗体经过验证可用于IC、IH、IH(P)、IP、WB中抗生长相关蛋白43的检测。

Biochem/physiol Actions

无论蛋白磷酸化状态如何，AB5312都能特异性识别GAP-43。这种抗血清在文献中被称为CG-1。

Physical form

未纯化

血清。液体，含0.02%叠氮化钠中作为防腐剂。

Preparation Note

自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。

Analysis Note

对照
已进行脊神经结扎的大鼠背根神经节组织，培养神经元

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Optogenetic spinal stimulation promotes new axonal growth and skilled forelimb recovery in rats with sub-chronic cervical spinal cord injury.

Sarah E Mondello et al.

Journal of neural engineering, 20(5) (2023-08-01)

Objective.Spinal cord injury (SCI) leads to debilitating sensorimotor deficits that greatly limit quality of life. This work aims to develop a mechanistic understanding of how to best promote functional recovery following SCI. Electrical spinal stimulation is one promising approach that

Palisade Endings of Extraocular Muscles Develop Postnatally Following Different Time Courses.

Roland Blumer et al.

Investigative ophthalmology & visual science, 58(12), 5105-5121 (2017-10-08)

To analyze in a frontal-eyed mammal (cat) the postnatal development of palisade endings in extraocular muscles (EOMs) and to compare the spatiotemporal and quantitative patterns of palisade endings among individual rectus muscles. Cats of different ages ranging from birth to

Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.

Yuetong Ding et al.

PloS one, 9(7), e101918-e101918 (2014-07-09)

Brachial plexus injury (BPI) and experimental spinal root avulsion result in loss of motor function in the affected segments. After root avulsion, significant motoneuron function is restored by re-implantation of the avulsed root. How much this functional recovery depends on

17β-estradiol protects human eyelid-derived adipose stem cells against cytotoxicity and increases transplanted cell survival in spinal cord injury.

Jing Zhou et al.

Journal of cellular and molecular medicine, 18(2), 326-343 (2014-01-01)

Stem cell transplantation represents a promising strategy for the repair of spinal cord injury (SCI). However, the low survival rate of the grafted cells is a major obstacle hindering clinical success because of ongoing secondary injury processes, which includes excitotoxicity

Preclinical long-term safety of intraspinal transplantation of human dorsal spinal GABA neural progenitor cells.

Xiaolong Zheng et al.

iScience, 26(11), 108306-108306 (2023-11-29)

Human pluripotent stem cell (hPSC)-derived neurons have shown promise in treating spinal cord injury (SCI). We previously showed that hPSC-derived dorsal spinal γ-aminobutyric acid (GABA) neurons can alleviate spasticity and promote locomotion in rats with SCI, but their long-term safety

抗生长相关蛋白43抗体

serum, Chemicon®

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

antibody form

antibody product type

clone

species reactivity

manufacturer/tradename

technique(s)

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Gene Information

说明

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Preparation Note

Analysis Note

Other Notes

Legal Information

Disclaimer

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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