biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... NOS2(4843)
General description
The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.
Immunogen
C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.
Application
Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Oxidative Stress
Oxidative Stress
Western blot: 1:1,000-1:2,500 (ECL).
Immunohistochemistry: 1:2,500-1:6,000 (ABC).
Optimal working dilutions must be determined by end user.
Immunohistochemistry: 1:2,500-1:6,000 (ABC).
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.
Physical form
Rabbit serum. Liquid containing 0.05% sodium azide.
Preparation Note
Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
存储类别
10 - Combustible liquids
wgk
WGK 1
相关内容
"Redox reactions are powerful chemical processes that involve the reduction and oxidation of proteins and metabolites found in living things. The mechanisms that regulate them are key to maintaining homeostasis and the balance between good health and disease pathology. Oxidative stress is the state where the delicate balance of redox biology is upset, and the pathology of oxidative stress are the cellular consequences to such an imbalance."
Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang, HJ; Isakow, W; Byers, DE; Engle, JT; Griffin, EA; Kemp, D; Brody, SL; Gropler et al.
Journal of Nuclear Medicine null
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Schuh, C; Wimmer, I; Hametner, S; Haider, L; Van Dam, AM; Liblau, RS; Smith, KJ; Probert et al.
Acta neuropathologica null
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.
Haider, L; Simeonidou, C; Steinberger, G; Hametner, S; Grigoriadis, N; Deretzi, G; Kovacs et al.
Journal of Neurology, Neurosurgery, and Psychiatry null
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| AB5384 | 04053252470691 |