AB5702
Anti-HES-1 Antibody
Chemicon®, from rabbit
别名:
Hairy 1
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选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rodent, human, mouse
Citations:
38
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-HES-1 Antibody, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rodent, human, mouse
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HES1(3280)
mouse ... Hes1(15205)
Analysis Note
Control
Human neural stem cells, Raji cell lysate.
Human neural stem cells, Raji cell lysate.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Neuronal & Glial Markers
Developmental Neuroscience
Neuronal & Glial Markers
This Anti-HES-1 Antibody is validated for use in IH, WB for the detection of HES-1.
Western Blot:
1:200-1:1,000 dilution using ECL.
Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.
Optimal working dilutions must be determined by the end user.
1:200-1:1,000 dilution using ECL.
Immunohistochemistry:
1:200-1:1,000 dilution of a previous lot worked.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Reactivity with other species has not been confirmed.
Recognizes HES-1 (Hairy family), a Helix-loop-helix class of transcription factor.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
29 kDa
Hes1 is a transcriptional repressor of genes that require a bHLH protein for their transcription. It may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Hes1 is expressed in developing neuroectodermal and endodermal endocrine tissues, and Hes1 deficient embryos show severe defects in neuronal development, as well as pancreatic hypoplasia.
Immunogen
Synthetic peptide.
Physical form
ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
Preparation Note
Stable for 1 year at -80ºC from date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Sheheryar Kabraji et al.
Breast cancer research : BCR, 19(1), 88-88 (2017-08-03)
Absence of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) correlates with poor long-term survival in patients with triple negative breast cancer (TNBC). These incomplete treatment responses are likely determined by mechanisms that enable cancer cells to resist being killed.
Rute M M Ferreira et al.
Cell reports, 21(4), 966-978 (2017-10-27)
The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophysiology and marker expression dependent on
Cédric S Tremblay et al.
BMC research notes, 11(1), 138-138 (2018-02-22)
The Hairy Enhancer of Split 1 (HES1) is a transcriptional repressor that regulates cellular proliferation and differentiation during development. We previously found an interaction between HES1 and Fanconi anemia (FA) proteins. FA is a hematological and developmental disorder caused by
Notch signaling in descending thoracic aortic aneurysm and dissection.
Zou, S; Ren, P; Nguyen, M; Coselli, JS; Shen, YH; LeMaire, SA
Testing null
Wen-Cheng Chung et al.
Oncoscience, 4(9-10), 131-138 (2017-11-17)
Kras mutations and increased Notch activation occur frequently in gallbladder cancer. However, their roles in gallbladder carcinogenesis have not been defined. This study was aimed at determining whether expression of mutant Kras was sufficient to induce gallbladder carcinoma and whether
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