Anti-Fibulin-5 Antibody

Fibulin-5 (also known as EVEC/DANCE) is an extracellular matrix protein. Fibulin-5 is most commonly found in blood vessels and cardiac valves during embryogenesis and in adult tissue that contains elastic fibers like the skin, lungs, uterus and aorta. Fibulin-5 travels to the surface of the elastic fibers and its activity is dependent on calcium. Fibulin-5 seems to work as a scaffold protein that facilitates the binding of the elastic fibers to cells and the formation of the elastic fibers themselves. Mutations of fibulin-5 have been associated with age-related macular degeneration (AMD) and cutis laxa (CL).

~54 kDa observed.
The calculated molecular weight is 50 kDa; however bands have been observed at ~56 kDa (Freeman, L.J., et al. (2005) Biochem. J. 388:1-5).

Epitope: Near C-terminus

KLH-conjugated linear peptide corresponding to human Fibulin-5 near the C-terminus.

Anti-Fibulin-5 Antibody detects level of Fibulin-5 & has been published & validated for use in WB.

Research Category
Cell Structure

Research Sub Category
ECM Proteins

This antibody recognizes Fibulin-5 near the C-terminus.

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Mouse heart tissue lysate

Evaluated by Western Blot in mouse heart tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected Fibulin-5 in 10 µg of mouse heart tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.