suitability
not suitable for immunohistochemistry (Paraffin), not suitable for Western blot
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, immunohistochemistry: suitable
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL4A1(1282)
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Immunogen
纯化人IV型胎盘胶原蛋白
Application
人IV型胶原蛋白ELISA：1:3,000
IV型胶原在人体组织低温切片上的间接免疫荧光可视化：1:20-1:40，仅限新鲜冷冻或丙酮固定标本。
斑点和狭缝印迹：1：300。
不推荐用于蛋白质印迹，也不推荐用于石蜡包埋组织切片。
最佳工作稀释度必须由最终用户进行确定。
IV型胶原在人体组织低温切片上的间接免疫荧光可视化：1:20-1:40，仅限新鲜冷冻或丙酮固定标本。
斑点和狭缝印迹：1：300。
不推荐用于蛋白质印迹，也不推荐用于石蜡包埋组织切片。
最佳工作稀释度必须由最终用户进行确定。
抗IV型胶原抗体可检测IV型胶原水平，已发布，经验证可用于ELISA、RIA、IH、IH（P）。
研究子类别
ECM 蛋白
ECM 蛋白
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
抗体与天然和热变性人IV型胶原蛋白反应。 与I、III、V型胶原的交叉反应性小于10%，与人II型胶原的交叉反应性小于1%。 抗血清通过固定化的人血浆蛋白和人I、III、V型胶原蛋白。人血浆蛋白不干扰与胶原蛋白的结合。
Physical form
亲和纯化的交叉吸收抗血清抗体。 PBS溶液，含甘露醇、葡聚糖，不含防腐剂。
形式：纯化
Preparation Note
收到货后，在-20°C下以未稀释等分试样可保存长达12个月。应避免反复冻/融循环。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Andrew R Findlay et al.
Neuromuscular disorders : NMD, 28(8), 675-679 (2018-06-24)
Mutations in MYH2 that encodes myosin heavy chain IIa cause both dominant and recessively inherited myopathies. Patients with dominantly inherited MYH2 missense mutations present with ophthalmoplegia and progressive proximal limb weakness. Muscle biopsy reveals rimmed vacuoles and inclusions, prompting this
Moa Lindgren et al.
Clinical & experimental metastasis, 38(2), 175-185 (2021-03-04)
No reliable, non-invasive biomarker of metastatic breast cancer (mBC) exists: circulating CA15-3 (cCA15-3) is the marker mostly used to monitor mBC. Circulating collagen IV (cCOLIV) has been evaluated in other metastatic cancers and has been found to be a promising
Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo.
Damsky, CH; Fitzgerald, ML; Fisher, SJ
The Journal of Clinical Investigation null
Yonghui Ding et al.
Advanced healthcare materials, 6(11) (2017-03-25)
Pathological modification of the subendothelial extracellular matrix (ECM) has closely been associated with endothelial activation and subsequent cardiovascular disease progression. To understand regulatory mechanisms of these matrix modifications, the majority of previous efforts have focused on the modulation of either
Malin Jansson et al.
Frontiers in molecular biosciences, 9, 904526-904526 (2022-06-14)
Breast cancer is the most common cause of cancer death among women worldwide. Localized breast cancer can be cured by surgery and adjuvant therapy, but mortality remains high for tumors that metastasize early. Type IV collagen is a basement membrane
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