AB758
Anti-Collagen Type I (COL1A1) Antibody
CHEMICON®, goat polyclonal
别名:
Anti-CAFYD, Anti-EDSARTH1, Anti-EDSC, Anti-OI1, Anti-OI2, Anti-OI3, Anti-OI4
产品名称
Anti-Collagen Type I Antibody, Chemicon®, from goat
生物来源
goat
质量水平
抗体形式
affinity purified immunoglobulin
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, bovine
制造商/商品名称
Chemicon®
技术
ELISA: suitable
dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
适用性
not suitable for immunohistochemistry (Paraffin)
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... COL1A1(1277)
免疫原
Human placental collagen type I isolated by limited pepsin digestion and selective salt precipitation.
应用
Anti-Collagen Type I Antibody is an antibody against Collagen Type I for use in DB, ELISA, IC, IH & WB.
Dot and slot blotting: 1:100-1:500
ELISA: 1:50-1:100
Indirect immunohistochemistry (frozen sections only): 1:10-1:20
Indirect immunocytochemistry: 1:10-1:20
Antibody reacts with human collagen I in reduced westerns with supernatant samples from serum-free cultures of human fibroblasts {LMF, personal communication}.
Not recommended for paraffin tissue sections.
Optimal working dilutions must be determined by the end user.
ELISA: 1:50-1:100
Indirect immunohistochemistry (frozen sections only): 1:10-1:20
Indirect immunocytochemistry: 1:10-1:20
Antibody reacts with human collagen I in reduced westerns with supernatant samples from serum-free cultures of human fibroblasts {LMF, personal communication}.
Not recommended for paraffin tissue sections.
Optimal working dilutions must be determined by the end user.
生化/生理作用
Recognizes Human type I collagen as demonstrated by ELISA. Less than 10% cross reactivity with collagen types II, III, IV, V, and VI. May show reactivity to type I collagen from other species. AB758 has not been tested with other extracellular matrix proteins (e.g., laminin, fibronectin).
外形
Affinity Purified immunoglobulin. Prior to purification the antisera was adsorbed against collagen types II, III, IV, V and VI immobilized on Sepharose™ 4B.. Liquid in 0.5 mL of 100 mM borate buffered saline, pH 8.0, no preservatives.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Sepharose is a trademark of Cytiva
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警示用语：
Danger
危险声明
危险分类
Repr. 1B
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
I Durán et al.
Developmental biology, 354(1), 160-172 (2011-03-23)
The skeleton of zebrafish fins consists of lepidotrichia and actinotrichia. Actinotrichia are fibrils located at the tip of each lepidotrichia and play a morphogenetic role in fin formation. Actinotrichia are formed by collagens associated with non-collagen components. The non-collagen components
Ben Yi Tew et al.
Oncogene, 38(21), 4002-4014 (2019-02-01)
The functional role of human derived stromal cells in the tumor microenviornment of CNS metastases (CM) remain understudied. The purpose of the current study was to isolate and characterize stromal cells of the tumor microenvironment in CM. Four different patient-derived
Maria-Grazia Spiga et al.
Investigative ophthalmology & visual science, 51(6), 3029-3041 (2010-01-22)
To design a glucocorticoid-inducible virus vector overexpressing recombinant matrix metalloproteinase 1 (MMP1) and counteract extracellular matrix deposition in the trabecular meshwork only when steroid is present. Endogenous MMP1 expression was measured in primary human trabecular meshwork cells (HTM) treated with
Michelle R Freeman et al.
American journal of physiology. Lung cellular and molecular physiology, 313(2), L360-L370 (2017-05-20)
Airway remodeling in asthma driven by inflammation involves proliferation of epithelial cells and airway smooth muscle (ASM), as well as enhanced extracellular matrix (ECM) generation and deposition, i.e., fibrosis. Accordingly, understanding profibrotic mechanisms is important for developing novel therapeutic strategies
Xiang-Hong Xu et al.
Experimental & molecular medicine, 51(2), 1-12 (2019-02-26)
Preeclampsia is a pregnancy-specific disorder that is a major cause of maternal and fetal morbidity and mortality with a prevalence of 6-8% of pregnancies. Although impaired trophoblast invasion in early pregnancy is known to be closely associated with preeclampsia, the
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