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ABC156

Sigma-Aldrich

Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody

from rabbit, purified by affinity chromatography

别名:

Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human

种属反应性(根据同源性预测)

rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology), canine (based on 100% sequence homology)

技术

immunohistochemistry: suitable (paraffin)
western blot: suitable

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此商品
CLS4844CLS4846CLS4866
feature

DNase free, barrier: no, endotoxin free, Bulk Pack, RNase free, filter: no, disposable

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, Bulk Pack

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, Bulk Pack

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, graduation, Bulk Pack

manufacturer/tradename

Corning 4845

manufacturer/tradename

Corning 4844

manufacturer/tradename

Corning 4846

manufacturer/tradename

Corning 4866

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

material

polypropylene , yellow tip

material

natural tip, polypropylene

material

blue tip, polypropylene

material

polypropylene , yellow tip

packaging

bag of 1000

packaging

bag of 1000, case of 10000

packaging

bag of 1000, case of 10000

packaging

bag of 1000, case of 1000

volume range

1-200 μL

volume range

1-200 μL

volume range

1-1000 μL

volume range

1-200 μL

一般描述

Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.
~74/40 kDa observed. An uncharacterized band may appear at ~65 kDa in some lysates.

免疫原

KLH-conjugated linear peptide corresponding to human BAG3.

应用

Detect BAG family molecular chaperone regulator 3 (BAG3) using this Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody validated for use in Western Blotting, IHC(P).
Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected BAG3 in human cardiac and renal tissues.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

外形

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

制备说明

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
DU145 cell lysate
Evaluated by Western Blot in DU145 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected BAG3 in 10 µg of DU145 cell lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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