YY1-associated protein 1 (YY1AP1), also known as Hepatocellular carcinoma susceptibility protein, Hepatocellular carcinoma-associated protein 2, is encoded by the gene name YY1AP1, HCCA2, and YY1AP. YY1AP1 has been demonstrated to enhance transcription activation by interacting with YY1. Recent studies have shown that YY1AP1 may play a role in cell cycle regulation. YY1AP1 interacts with YY1 and MAD2L2. YY1AP1 is expressed ubiquitously. YY1AP1 has been detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. At very low levels, YY1AP1 has been detected in healthy liver. YY1AP1 is highly expressed in most liver carcinomas.

Epitope: Near N-terminal

KLH-conjugated linear peptide corresponding to human YY1AP1 near the N-terminal.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This Anti-YY1AP1 antibody is validated for use in WB, IH for the detection of YY1AP1.

Western Blotting Analysis: 0.5 µg/mL from a representative lot detected YY1AP1 in 10 µg of C2C12, Hek293, HeLa, HepG2, human placenta, Huvec, Jurkat, L6, mouse brain, NIH-3T3, PC12, PC3, and Raw 264.7 lysate.
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected YY1AP1 in human cerebellum, mouse hindbrain, and mouse cerebellum tissue.

Evaluated by Western Blotting in A431 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected YY1AP1 in 10 µg of A431 cell lysate.

~90 kDa observed. The endogenous YY1AP protein signal is found at 90 kDa, in agreement with the predicted protein size of 750 amino acids derived from open reading frame (Wang, C.Y., et al. (2004). J. Biol. Chem. 279:17750-17755).

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.