Zinc transporter ZIP6, also known as Estrogen-regulated protein LIV-1 or Solute carrier family 39 member 6 orZrt- and Irt-like protein 6 (ZIP-6), and encoded by the gene name ZIP6 or SLC39A6 or LIV1 is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP-6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP-6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP-6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP-6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.

~48 and ~85 kDa observed. Uncharacterized bands may be observed in some lysate(s). Uniprot describes 2 isoforms produced by alternative splicing at ~49 kDa and ~85 kDa

Epitope: center region

KLH-conjugated synthetic peptide corresponding to the center region of human Anti-ZIP-6.

Anti-ZIP-6 Antibody detects level of ZIP-6 & has been published & validated for use in ZIP-6.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected Anti-ZIP-6 in mouse lung tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

This antibody is recognizes isoforms at ~48 and ~85 kDa and is predicted to not cross-react with other ZIP family members.

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Western Blotting in mouse lung tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected Anti-ZIP-6 in mouse lung tissue lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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