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Merck
CN

ABC924

Anti-CtBP-2 Antibody

from rabbit, purified by affinity chromatography

别名:

C-terminal-binding protein 2, CtBP-2, CtBP2

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

Anti-CtBP-2 Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

chicken (based on 100% sequence homology), bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), horse (based on 100% sequence homology), sheep (based on 100% sequence homology), mouse (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001077383

UniProt accession no.

P56545

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CTBP2(1488)

Analysis Note

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.25 µg/mL of this antibody detected CtBP-2 in 10 µg of HeLa cell lysate.

Application

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected CtBP-2 in human breast cancer cells, human kidney, human ovarian cancer cells, and human prostate cancer cells.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-CtBP-2 Antibody is validated for use in Western Blotting, Immunohistochemistry for the detection of CtBP-2 .

Biochem/physiol Actions

Expected to react with spliced variant Ribeye (isoform 2).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

C-terminal-binding protein 2 (UniProt P56545; also known as CtBP2) is a nuclear protein encoded by the CTBP2 gene (Gene ID 1488) in human. CtBP1 and CtBP2 are closely related proteins that are encoded by the vertebrate genome and perform both unique and duplicative functions. Upon activation by nicotinamide adenine dinucleotide binding to their dehydrogenase domains, CtBP1 and CtBP2 exert transcriptional repression activity primarily via recruitment of a corepressor complex that consists of histone deacetylases (HDACs) and histone methyltransferases, although CtBPs can also repress transcription through HDAC-independent mechanisms. A critical function of CtBPs lies in the transcriptional repression of pro-apoptotic genes such as Bax, Puma, Bik, and Noxa. CtBP2 is essential for proper development of the nervous system. Acetylation by histone acetyl transferase p300 regulates CtBP2 activity and subcellular localization, while microenvironmental oxygen levels influences the dimerization, acetylation, and thereby the activity of CtBP2 in proliferating neural stem cells (NSCs).
~50 kDa observed. 48.9 kDa (Isoform 1; calculated); 109.2 kDa (Isoform 2/Ribeye; calculated)." ==> ~50 kDa observed. 48.9 kDa (Isoform 1; calculated); 109.2 kDa (Isoform 2/Ribeye; calculated).

Immunogen

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human CtBP-2.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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相关内容

White Paper: Further considerations of antibody validation and usage.
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System

A major focus of breast cancer research is to understand the mechanisms responsible for disease progression and drug resistance. Toward that end, it has been found that approximately two thirds of all human breast carcinomas overexpress the Estrogen Receptor α (ERα) protein and it remains the primary pharmacological target for endocrine therapy1,2. The normal cellular function of ERα is as a transcription factor that mediates a wide variety of physiological processes, many of which are dependent upon phosphorylation of the receptor at specific amino acid residues3,4. Indeed, ERα is known to be phosphorylated at a multitude of different sites, yet how these all correlate to disease remains unclear5. Here, we interrogated multiple sites of ERα for phosphorylation status by screening an extensive panel of different breast cancer patient samples and other non-breast cancer tissue microarray (TMA) slide samples to determine their relevance to disease.

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