Protein prune homolog, otherwise known as PRUNE or Drosophila-related expressed sequence 17, is a phosphodiesterase enzyme belonging to the PPase class C family. PRUNE targets cAMP and cGMP second messengers and plays a role in cell proliferation and motility. It is overexpressed in various sarcomas, including leiomyosarcomas, malignant fibrous histiocytomas, and malignant liposarcomas.

~57 kDa observed

KLH-conjugated linear peptide corresponding to human PRUNE.

Detect PRUNE using this Anti-PRUNE Antibody validated for use in Western Blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
HeLa S3 cell lysate

Evaluated by Western Blot in HeLa S3 cell lysate.

Western Blot Analysis: A 1:5,000 dilution of this antibody detected PRUNE in 10 µg of HeLa S3 cell lysate.

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