ABE217
抗-CUX1抗体，a.a.861
from rabbit, purified by affinity chromatography
别名:
Homeobox protein cut-like 1, CCAAT displacement protein, CDP, Homeobox protein cux-1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoprecipitation (IP)
western blot
western blot
Species reactivity:
human
Citations:
5
Technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-CUX1抗体，a.a.861, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CUX1(1523)
Analysis Note
对照
HeLa 核提取物
HeLa 核提取物
通过蛋白质印迹在 HeLa 核提取物中进行了评估。
蛋白质印迹分析：0.25 µg/mL代表性批次在10 µg HeLa核提取物中检测到CUX1。
蛋白质印迹分析：0.25 µg/mL代表性批次在10 µg HeLa核提取物中检测到CUX1。
Application
免疫沉淀分析：1.25 µg代表性批次免疫沉淀500 µg HeLa核提取物中的CUX1。
Alexa Fluor™是Life Technologies的注册商标。
Alexa Fluor™是Life Technologies的注册商标。
检测Cux1使用该兔多克隆抗体，抗CUX1抗体，a.a.861经验证可用于蛋白质印迹& IP。
研究子类别
转录因子
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
其他同源性：小鼠（95% 序列同源性）。
该抗体识别CUX1从861开始的氨基酸区域。该抗体预期可与全部已知的CUX1亚型发生交叉反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
同源盒蛋白切样1（CUX1）也称为CCAAT置换蛋白（CDP）和同源盒蛋白cux-1。CUX1被认为可能通过防止启动子上CCAAT因子的结合来抑制参与哺乳动物发育的发育调节基因的表达。CUX1还通过与基质附着区β（MARβ）结合来抑制T细胞受体（TCR）β增强子功能，并且是nf-munr阻遏物的组分，其与免疫球蛋白重链增强子的基质附着区（MAR）结合。
观察值~200 kDa和~ 110 kDa。Uniprot描述了11种不同的亚型。全长蛋白已被描述为200 kDa，并被蛋白水解切割成p150，p110，p90和p80亚型。此外，p75亚型是选择性剪接的结果（Sansregret, L, et al. (2008).Gene.412(1-2):84-94.）。在某些细胞裂解物中可能会观察到未表征的条带。
Immunogen
GST标记的重组蛋白对应于人CUX1的从861开始的氨基酸区域。
表位：从861开始的氨基酸区域
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Nele Vollersen et al.
Bone research, 9(1), 48-48 (2021-11-12)
The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts. Although such an influence was supported by subsequent studies
Balraj Singh et al.
PloS one, 11(7), e0159072-e0159072 (2016-07-09)
We have previously shown that only 0.01% cells survive a metabolic challenge involving lack of glutamine in culture medium of SUM149 triple-negative Inflammatory Breast Cancer cell line. These cells, designated as SUM149-MA for metabolic adaptability, are resistant to chemotherapeutic drugs
Kawssar Harb et al.
eLife, 11 (2022-03-10)
In the neocortex, functionally distinct areas process specific types of information. Area identity is established by morphogens and transcriptional master regulators, but downstream mechanisms driving area-specific neuronal specification remain unclear. Here, we reveal a role for RNA-binding proteins in defining
Carla G Silva et al.
Cell, 172(5), 1063-1078 (2018-02-24)
Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause
Takashi Irie et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(42), e2307972120-e2307972120 (2023-10-09)
Although generating new neurons in the ischemic injured brain would be an ideal approach to replenish the lost neurons for repairing the damage, the adult mammalian brain retains only limited neurogenic capability. Here, we show that direct conversion of microglia/macrophages
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