ABE413
抗NF-E2相关因子2抗体
from rabbit, purified by affinity chromatography
别名:
Nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2, HEBP1, Nuclear factor erythroid derived 2-like 2
产品名称
抗NF-E2相关因子2抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), rat (based on 100% sequence homology)
packaging
antibody small pack of 25 μg
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NFE2L2(4780)
Immunogen
与人NF-E2相关因子2 C端相对应的KLH偶联肽。
表位：C末端
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Analysis Note
对照
Ramos细胞裂解液
Ramos细胞裂解液
通过蛋白质印迹对Ramos细胞裂解液进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg Ramos细胞裂解液中检测到NF-E2相关因子2。
蛋白质印迹分析：1 µg/mL该抗体在10 µg Ramos细胞裂解液中检测到NF-E2相关因子2。
Application
抗NF-E2相关因子2抗体是一种高度特异性的兔多克隆抗体，靶向NF-E2相关因子2 & 已通过蛋白质印迹和&ICC测试。
研究子类别
转录因子
转录因子
研究类别
表观遗传学&核功能
表观遗传学&核功能
蛋白印迹分析: 1 µg/mL代表性批次产品在10 µg Jurkat细胞裂解液中检测到NF-E2相关因子2。
免疫细胞化学分析：一个代表性批次产品以1：200的稀释度，在未经处理和过氧化氢处理的细胞中检测到NF-E2相关因子2（注意：细胞质染色在氧化应激下增加。）
免疫细胞化学分析：一个代表性批次产品以1：200的稀释度，在未经处理和过氧化氢处理的细胞中检测到NF-E2相关因子2（注意：细胞质染色在氧化应激下增加。）
Biochem/physiol Actions
该抗体可识别NF-E2相关因子2的C末端
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
NF-E2相关因子2（核因子红系2相关因子2）是一种转录激活因子，可与目标基因启动子区域的抗氧化反应元件（ARE）结合。NF-E2相关因子2可介导基因对氧化应激的协同上调。NF-E2相关因子2也可能参与β-珠蛋白簇基因的转录激活。NF-E2相关因子2广泛表达，在成年肌肉、肾脏、肺、肝和胎儿肌肉中表达量最高。
观测值~75 kDa。已知存在68 kDa（异构体1）和66 kDa（异构体2）的两个异构体。由于在Nrf2中发现了大量酸性残基，这导致其在SDS-PAGE中发生异常迁移，因此在〜75 kDa处观察到该蛋白质（Abu-Bakar, A., et al. (2007) Drug Metab Dispos.35(5):787-794.）。NF-E2相关因子2的泛素化形式可在〜110 kDa处观察到（Li, J., et al. (2005).Toxicol Sci. 83(2):313-328.）。
Physical form
亲和纯化
纯化的兔单克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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