ABE44-S
抗-三甲基组蛋白 H3（Lys27）抗体，试用装
from rabbit, purified by affinity chromatography
别名:
H3K27me3, Histone H3 (trimethyl K27), H3 histone family, member T, Histone 3, H3, Histone cluster 3, H3, H3K27me3
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选择尺寸
关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, mouse
Application:
dot blot
immunocytochemistry
inhibition assay
western blot
immunocytochemistry
inhibition assay
western blot
Technique(s):
dot blot: suitable
immunocytochemistry: suitable
inhibition assay: suitable (peptide)
western blot: suitable
immunocytochemistry: suitable
inhibition assay: suitable (peptide)
western blot: suitable
Citations:
3
Uniprot accession no.:
产品名称
抗-三甲基组蛋白 H3（Lys27）抗体，试用装, from rabbit, purified by affinity chromatography
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
technique(s)
dot blot: suitable
immunocytochemistry: suitable
inhibition assay: suitable (peptide)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
trimethylation (Lys27)
Quality Level
Gene Information
human ... HIST1H3F(8968)
Analysis Note
通过蛋白质印迹在HeLa酸提取物和重组组蛋白H3中进行评估。
蛋白质印迹分析：0.1 µg/mL该抗体在10 µg HeLa 酸提取物中检测到组蛋白H3。
蛋白质印迹分析：0.1 µg/mL该抗体在10 µg HeLa 酸提取物中检测到组蛋白H3。
Application
抗-三甲基组蛋白 H3（Lys4）抗体是兔多克隆抗体，用于检测在赖氨酸27处的组蛋白H3三甲基化（H3K73me）。该纯化Ab是通过在WB、ICC、PIA中验证的斑点印迹（DB）&验证的特异性。小包装尺寸是筛选应用的理想选择。
Biochem/physiol Actions
预计具有广泛的物种交叉反应性。
General description
组蛋白H3是核小体的核心成分。核小体将DNA包裹并压缩到染色质中，从而限制了DNA进入需要DNA作为模板的细胞机制中的可及性。它们在转录调节、DNA修复、DNA复制和染色体稳定性中起着核心作用。DNA的可及性是通过对组蛋白进行复杂的翻译后修饰（也称为组蛋白编码）和核小体重塑来调节的。组蛋白H3赖氨酸27甲基化（H3K27）与异染色质形成和转录抑制有关。
~17 kDa
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Danyang Li et al.
International journal of biological sciences, 15(1), 69-80 (2019-01-22)
EZH2 plays vital roles in epigenetic regulation, neuronal development and cancer progression. Here a novel EZH2 variant, namely EZH2-X9 (X9 for short) resulting from alternative splicing, was isolated, identified and functionally characterized. X9 was highly expressed in the brains of
Shumeng Liu et al.
Molecular cell, 67(5), 853-866 (2017-08-15)
Lysine crotonylation (Kcr) is a newly identified histone modification that is associated with active transcription in mammalian cells. Here we report that the chromodomain Y-like transcription corepressor CDYL negatively regulates histone Kcr by acting as a crotonyl-CoA hydratase to convert
Huiming Chen et al.
Oncotarget, 6(15), 13049-13059 (2015-05-07)
Polycomb repressive complex 2 (PRC2), which is responsible for the trimethylation of H3K27 (H3K27me3), plays a part in tumorigenesis, development and/or maintenance of adult tissue specificity. The pivotal role of PRC2 in cancer makes it a therapeutic target for epigenetic
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